Immunohistochemical study of estradiol, epidermal growth factor, transforming growth factor alpha and epidermal growth factor receptor in endometrial neoplasia.
Immunohistochemical study of estradiol, epidermal growth factor, transforming growth factor alpha and epidermal growth factor receptor in endometrial neoplasia.
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子宫内膜肿瘤中雌二醇、表皮生长因子、转化生长因子α和表皮生长因子受体的免疫组织化学研究。
DOI：
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发表时间：
1996
影响因子：
2.4
通讯作者：
T. Tamaya
中科院分区：
文献类型：
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作者：
Y. Yokoyama;Y. Takahashi;M. Hashimoto;S. Morishita;T. Tamaya
在总共113例子宫内膜肿瘤中，我们研究了雌二醇（E2）、表皮生长因子（EGF）、转化生长因子α（TGF α）和表皮生长因子受体（EGFR）的免疫组织化学表达。61%的肿瘤呈E2阳性。E2免疫反应性与高组织学分级和早期临床分期相关。EGF或EGFR的阳性表达率分别为25.6%和53.1%。然而，这与组织学分级或临床分期无关。另一方面，TGF-α免疫反应在67%的子宫内膜肿瘤中被发现，并与不良的组织学分级和先进的阶段。列联表表明E2和TGF α的状态之间存在显著的负相关。E2、EGF和EGFR或E2、TGF α和EGFR同时表达的子宫内膜癌分别为6.8%和15.9%。这些结果表明，绝大多数子宫内膜癌逃避EGF和E2或TGF α和E2的自分泌/旁分泌生长调节，TGF α可能参与子宫内膜癌的进展。
In a total of 113 cases of endometrial neoplasm, we studied the immunohistochemical expression of estradiol (E2), epidermal growth factor (EGF), transforming growth factor alpha (TGFalpha), and epidermal growth factor receptor (EGFR). Positive immunoreactivity of E2 was found in 61% of the neoplasms. E2 immunoreactivity correlated well with high histologic grade and early clinical stage. Positive immunoreactivity for EGF or EGFR was found in 25.6% or 53.1% of the neoplasms, respectively. However, this was unrelated to histologic grade or clinical stage. On the other hand, TGFalpha immunoreactivity was found in 67% of endometrial neoplasias and was correlated with poor histologic grade and advanced stage. Contingency tables indicated a significant negative association between the status of E2 and that of TGFalpha. Simultaneous expression of E2, EGF and EGFR, or E2, TGFalpha and EGFR was found in 6.8% and 15.9% of endometrial carcinomas, respectively. These results suggest that a predominant number of endometrial carcinomas escape autocrine/paracrine growth regulation by EGF and E2 or TGFalpha and E2, and that TGFalpha may be involved in the progression of endometrial carcinoma.
影响因子：
11.2
作者：
R. Dickson;S. Bates;M. McManaway;M. Lippman
通讯作者：
R. Dickson;S. Bates;M. McManaway;M. Lippman