Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-β)

Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-β)
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自噬抑制使肾小管上皮细胞对转化生长因子 beta (TGF-β) 诱导的 G1 停滞敏感

DOI:
10.12659/msm.922673
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发表时间:
2020-04
影响因子:
3.1
通讯作者:
Hua-feng Liu
Hua-feng Liu
中科院分区:
医学4区
文献类型:
--
作者:
Chen Yang;Hong-luan Wu;Zhi-hang Li;Xiao-cui Chen;Hong-yong Su;Xiao-yan Guo;Ning An;Kai-peng Jing;Qing-jun Pan;Hua-feng Liu

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研究背景细胞周期阻滞和自噬参与了转化生长因子(transforming growth factor,TGF)-β介导的肾小管上皮细胞(tubular epithelial cells,TECs)表型改变和肾小管间质纤维化。但TGF-β诱导的细胞自噬与细胞周期阻滞的关系尚不清楚。
BackgroundCell cycle arrest and autophagy have been demonstrated to be involved in various transforming growth factor (TGF)-β-mediated phenotype alterations of tubular epithelial cells (TECs) and tubulointerstitial fibrosis. But the relationship between cell cycle arrest and the autophagy induced by TGF-β has not been explored well.
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