Interactions Between Bisphenol A Exposure and GSTP1 Polymorphisms in Childhood Asthma.
Interactions Between Bisphenol A Exposure and GSTP1 Polymorphisms in Childhood Asthma.
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DOI：
10.4168/aair.2018.10.2.172
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Wang IJ
中科院分区：
文献类型：
--
作者：
Lin TJ;Karmaus WJJ;Chen ML;Hsu JC;Wang IJ
双酚A（BPA）暴露可能会增加哮喘的风险。氧化应激相关基因、谷胱甘肽S-转移酶（GSTM 1、GSTP 1）、锰超氧化物歧化酶、过氧化氢酶、髓过氧化物酶和微粒体环氧化物水解酶的遗传多态性可能与BPA暴露有关。目的是评估氧化应激基因是否调节BPA暴露与哮喘的关系。我们进行了一项病例对照研究，包括126名哮喘儿童和327名对照。通过超高效液相色谱/串联质谱法测定尿液双酚A葡萄糖醛酸苷（BPAG）水平，并通过TaqMan试验分析遗传变异。收集了关于哮喘和环境暴露的信息。方差分析和Logistic回归分析，以确定基因型和尿BPAG水平与哮喘的关系。BPAG水平与哮喘显著相关（校正比值比[aOR]，浓度每增加1. 29个对数单位; 95%置信区间[CI]，1. 08 - 1. 55）。与GG基因型相比，GSTP 1 AA基因型儿童的尿BPAG浓度更高（几何平均值[标准误]，12.72 [4.16] vs 11.42 [2.82]; P=0.036）。在BPAG高的儿童中，GSTP 1 AA基因型与哮喘的几率比GG基因型更高（aOR，4.84; 95%CI，1.0223.06）。GSTP 1变体与尿BPA代谢物水平相关。氧化应激基因可能调节BPA暴露对哮喘的影响。
Bisphenol A (BPA) exposure may increase the risk of asthma. Genetic polymorphisms of oxidative stress-related genes, glutathione S-transferases (GSTM1, GSTP1), manganese superoxide dismutase, catalase, myeloperoxidase, and microsomal epoxide hydrolase may be related to BPA exposure. The aim is to evaluate whether oxidative stress genes modulates associations of BPA exposure with asthma. We conducted a case-control study comprised of 126 asthmatic children and 327 controls. Urine Bisphenol A glucuronide (BPAG) levels were measured by ultra-performance liquid chromatography/tandem mass spectrometry, and genetic variants were analyzed by a TaqMan assay. Information on asthma and environmental exposure was collected. Analyses of variance and logistic regressions were performed to determine the association of genotypes and urine BPAG levels with asthma. BPAG levels were significantly associated with asthma (adjusted odds ratio [aOR], 1.29 per log unit increase in concentration; 95% confidence interval [CI], 1.081.55). Compared to the GG genotype, children with a GSTP1 AA genotype had higher urine BPAG concentrations (geometric mean [standard error], 12.72 [4.16] vs 11.42 [2.82]; P=0.036). In children with high BPAG, the GSTP1 AA genotype was related to a higher odds of asthma than the GG genotype (aOR, 4.84; 95% CI, 1.0223.06). GSTP1 variants are associated with urine BPA metabolite levels. Oxidative stress genes may modulate the effect of BPA exposure on asthma.
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