Neurosteroidogenesis: insights from studies of songbirds.
Neurosteroidogenesis: insights from studies of songbirds.
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DOI：
10.1111/j.1365-2826.2011.02150.x
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发表时间：
2012-01
影响因子：
3.2
通讯作者：
Remage-Healey L
中科院分区：
文献类型：
--
作者：
Schlinger BA;Remage-Healey L
The long-held dogma that the brain is a target of steroids produced by peripheral organs has delayed widespread acceptance of the functional importance of neurosteroidogenesis. Comparative studies have been vital for establishing the key actions of gonadal and adrenal hormones on brain and behavior. No doubt, studies across diverse phyla will continue to be crucial for revealing the true significance of neurosteroidogenesis to proper function of the vertebrate brain. Here we review work out of our lab and others highlighting advances to our understanding of brain steroid synthesis and action using songbirds as animal models. These studies show that steroidogenic transporters and enzymes are present in the songbird brain and their expression and/or activities are subject to developmental, seasonal or short-term regulation. Our work in a songbird points to synaptic synthesis of neuroactive steroids and fast, peri-synaptic membrane actions. Combined with evidence for rapid steroidal control of behavior, these studies firmly establish a neuromodulatory role for avian neurosteroids. We hope this work will join with that of other species to embolden acceptance of neurosteroidal signaling as a core property of vertebrate neurobiology.
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影响因子：
2.4
作者：
London SE;Clayton DF
通讯作者：
Clayton DF
影响因子：
1.7
作者：
ARNOLD, AP;SCHLINGER, BA
通讯作者：
SCHLINGER, BA
影响因子：
4.8
作者：
Balthazart, J;Baillien, M;Ball, GF
通讯作者：
Ball, GF
影响因子：
3.4
作者：
Balthazart, J;Baillien, M;Ball, GF
通讯作者：
Ball, GF
影响因子：
4.1
作者：
Hojo, Yasushi;Murakami, Gen;Kawato, Suguru
通讯作者：
Kawato, Suguru