Viral OTU deubiquitinases: a structural and functional comparison.

Viral OTU deubiquitinases: a structural and functional comparison.
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DOI:
10.1371/journal.ppat.1003894
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发表时间:
2014-03
期刊:
影响因子:
6.7
通讯作者:
Mark BL
Mark BL
中科院分区:
医学1区
文献类型:
--
作者:
Bailey-Elkin BA;van Kasteren PB;Snijder EJ;Kikkert M;Mark BL

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最近的研究表明,由三种非常不同的RNA病毒群编码的蛋白酶与卵巢肿瘤(OTU)脱泛素酶(DUBs)超家族的酶具有结构相似性。这些最新报告的迅速发表阻碍了对这些病毒酶的共同特征的适当认识和讨论。在这里,我们提供了这些病毒编码的OTU dub的简要结构和功能比较。有趣的是,尽管它们共同的结构特征和底物特异性暂时将它们置于同一个蛋白酶超家族中,但它们也表现出有趣的差异,从而引发了对它们起源的猜测。
Recent studies have revealed that proteases encoded by three very diverse RNA virus groups share structural similarity with enzymes of the Ovarian Tumor (OTU) superfamily of deubiquitinases (DUBs). The publication of the latest of these reports in quick succession prevented proper recognition and discussion of the shared features of these viral enzymes. Here we provide a brief structural and functional comparison of these virus-encoded OTU DUBs. Interestingly, although their shared structural features and substrate specificity tentatively place them within the same protease superfamily, they also show interesting differences that trigger speculation as to their origins.
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