Potential epigenetic mechanism in non-alcoholic Fatty liver disease.
Potential epigenetic mechanism in non-alcoholic Fatty liver disease.
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非酒精性脂肪肝病的潜在表观遗传机制。
DOI：
10.3390/ijms16035161
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发表时间：
2015-03-05
影响因子：
5.6
通讯作者：
Qiao L
中科院分区：
文献类型：
--
作者：
Sun C;Fan JG;Qiao L
非酒精性脂肪性肝病（NAFLD）的特征是肝脏中的脂肪过度积累。它的范围从简单的脂肪变性到其更具侵略性的形式，非酒精性脂肪性肝炎（NASH），如果它持续很长一段时间，可能会发展成肝纤维化，肝硬化或肝细胞癌（HCC）。然而，NAFLD及其相关代谢紊乱的确切发病机制尚不清楚。表观遗传变化是在转录水平上发生的稳定改变，而不改变潜在的DNA序列。DNA甲基化、组蛋白修饰和microRNA是表观遗传修饰的最常见形式。表观遗传学改变涉及肝脏脂质代谢、胰岛素抵抗、线粒体损伤、氧化应激反应和炎性细胞因子的释放的调节，所有这些都与NAFLD的发生和进展有关。本文就NAFLD的表观遗传学机制作一综述。阐明表观遗传因素可能有助于NAFLD早期诊断生物标志物的鉴定和治疗策略的制定。
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive fat accumulation in the liver. It ranges from simple steatosis to its more aggressive form, non-alcoholic steatohepatitis (NASH), which may develop into hepatic fibrosis, cirrhosis, or hepatocellular carcinoma (HCC) if it persists for a long time. However, the exact pathogenesis of NAFLD and the related metabolic disorders remain unclear. Epigenetic changes are stable alterations that take place at the transcriptional level without altering the underlying DNA sequence. DNA methylation, histone modifications and microRNA are among the most common forms of epigenetic modification. Epigenetic alterations are involved in the regulation of hepatic lipid metabolism, insulin resistance, mitochondrial damage, oxidative stress response, and the release of inflammatory cytokines, all of which have been implicated in the development and progression of NAFLD. This review summarizes the current advances in the potential epigenetic mechanism of NAFLD. Elucidation of epigenetic factors may facilitate the identification of early diagnositic biomarkers and development of therapeutic strategies for NAFLD.
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作者：
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