State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease.
State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease.
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DOI：
10.1002/alz.12372
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Vergallo A
中科院分区：
文献类型：
--
作者：
Hampel H;Shaw LM;Aisen P;Chen C;Lleó A;Iwatsubo T;Iwata A;Yamada M;Ikeuchi T;Jia J;Wang H;Teunissen CE;Peskind E;Blennow K;Cummings J;Vergallo A
在开发阿尔茨海默病（AD）的疾病修饰疗法（DMT）方面的最新进展，以及认识到AD病理生理学在临床症状出现之前几十年就出现了，需要医疗保健系统向生物标志物指导的早期检测，诊断和治疗决策的范式转变。在临床实践中适当纳入脑脊液生物标志物分析是系统准备就绪的重要一步，以适应AD诊断和适当使用DMT的需求-一旦它们可用。然而，腰椎穿刺（LP）在疑似神经退行性疾病（如AD）患者中的使用并不一致，并且其效用和安全性的看法在医学专业以及地区和国家之间存在很大差异。本综述描述了关于LP在老年人中安全性特征的最新证据，讨论了LP相关不良事件的风险因素，并为LP在疑似AD患者中的优化使用和全球实施提供了建议和展望。
Recent advances in developing disease‐modifying therapies (DMT) for Alzheimer's disease (AD), and the recognition that AD pathophysiology emerges decades before clinical symptoms, necessitate a paradigm shift of health‐care systems toward biomarker‐guided early detection, diagnosis, and therapeutic decision‐making. Appropriate incorporation of cerebrospinal fluid biomarker analysis in clinical practice is an essential step toward system readiness for accommodating the demand of AD diagnosis and proper use of DMTs—once they become available. However, the use of lumbar puncture (LP) in individuals with suspected neurodegenerative diseases such as AD is inconsistent, and the perception of its utility and safety differs considerably among medical specialties as well as among regions and countries. This review describes the state‐of‐the‐art evidence concerning the safety profile of LP in older adults, discusses the risk factors for LP‐associated adverse events, and provides recommendations and an outlook for optimized use and global implementation of LP in individuals with suspected AD.
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影响因子：
14
作者：
通讯作者：
--
影响因子：
2.6
作者：
Barnett JH;Lewis L;Blackwell AD;Taylor M
通讯作者：
Taylor M
影响因子：
4.8
作者：
Ali, Saad;Qandeel, Monther;Yang, Carina W.
通讯作者：
Yang, Carina W.
影响因子：
3.4
作者：
Andreasson U;Perret-Liaudet A;van Waalwijk van Doorn LJ;Blennow K;Chiasserini D;Engelborghs S;Fladby T;Genc S;Kruse N;Kuiperij HB;Kulic L;Lewczuk P;Mollenhauer B;Mroczko B;Parnetti L;Vanmechelen E;Verbeek MM;Winblad B;Zetterberg H;Koel-Simmelink M;Teunissen CE
通讯作者：
Teunissen CE
DOI：
10.1016/j.jalz.2011.03.008
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Albert MS;DeKosky ST;Dickson D;Dubois B;Feldman HH;Fox NC;Gamst A;Holtzman DM;Jagust WJ;Petersen RC;Snyder PJ;Carrillo MC;Thies B;Phelps CH
通讯作者：
Phelps CH