Prognostic significance of osteopontin expression in early-stage non-small-cell lung cancer.
Prognostic significance of osteopontin expression in early-stage non-small-cell lung cancer.
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DOI：
10.1038/sj.bjc.6602715
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发表时间：
2005-08-22
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
骨桥蛋白（OPN）是一种多功能蛋白质，近年来发现与多种恶性肿瘤的发生、发展和转移有关。由于非小细胞肺癌（NSCLC）的预后仍然很差，结果的预测因素很少，本研究的目的是评估OPN是否可能参与NSCLC的生物学，因此代表一种预后标志物和新的治疗试验的目标。采用免疫组化法检测136例I期NSCLC患者中OPN的表达，以具有胞浆免疫反应性的肿瘤细胞的百分比进行评价。该系列的中值（20%的阳性细胞）用作区分具有低（<20%）OPN表达的肿瘤与具有高（> 20%）OPN表达的肿瘤的截止值。高水平的OPN与我们患者的总体（P=0.034）和无病生存期（P=0.011）较短之间存在统计学显著相关性。我们的研究结果支持这一假设，即高OPN表达是一个显着不利的预后因素与I期NSCLC患者的生存。这一结论在早期肿瘤的生物学特征和治疗机会方面具有显著的重要性。
Osteopontin (OPN) is a multifunctional protein, which has recently been shown to be linked to tumorigenesis, progression and metastasis in different malignancies. Since non-small-cell lung cancer (NSCLC)'s prognosis remains bad, with few predictors of outcome, the purpose of this study was to evaluate if OPN might be involved in NSCLC's biology and therefore represent a prognostic marker and a target for new therapeutic trials. Immunohistochemistry was used to detect OPN expression, evaluated as percentage of neoplastic cells with cytoplasmic immunoreactivity, in a wide cohort of patients with stage I NSCLC (136 cases). The median value of this series (20% of positive cells) was used as the cutoff value to distinguish tumours with low (<20%) from tumours with high (⩾20%) OPN expression. A statistically significant correlation between high levels of OPN and shorter overall (P=0.034) and disease-free (P=0.011) survival in our patients was shown. Our results support the hypothesis that high OPN expression is a significantly unfavourable prognostic factor for the survival of patients with stage I NSCLC. This conclusion has notable importance in terms of the biological characterization of early-stage tumours and therapeutic opportunities.
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影响因子：
5.3
作者：
Chambers, AF;Wilson, SM;Casson, AG
通讯作者：
Casson, AG
影响因子：
11.5
作者：
Coppola, D;Szabo, M;Yeatman, TJ
通讯作者：
Yeatman, TJ
DOI：
10.2174/1566524013363339
发表时间：
2001-11-01
期刊：
Current Molecular Medicine (Hilversum)
影响因子：
--
作者：
Furger, Kara A.;Menon, Rajashree K.;Chambers, Ann F.
通讯作者：
Chambers, Ann F.
影响因子：
8
作者：
SORENSEN, ES;HOJRUP, P;PETERSEN, TE
通讯作者：
PETERSEN, TE
DOI：
10.1164/ajrccm.160.4.9807094
发表时间：
1999-10-01
影响因子：
24.7
作者：
Shijubo, N;Uede, T;Abe, S
通讯作者：
Abe, S