Regulation of Muscle Glycogen Metabolism during Exercise: Implications for Endurance Performance and Training Adaptations.
Regulation of Muscle Glycogen Metabolism during Exercise: Implications for Endurance Performance and Training Adaptations.
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DOI：
10.3390/nu10030298
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发表时间：
2018-03-02
期刊：
影响因子：
5.9
通讯作者：
Morton JP
中科院分区：
文献类型：
--
作者：
Hearris MA;Hammond KM;Fell JM;Morton JP
自从20世纪60年代末引入肌肉活组织检查技术以来，我们对肌肉糖原储存和代谢调节的理解有了很大的进步。肌肉糖原分解和碳水化合物(CHO)氧化速率受运动强度、持续时间、训练状态和底物可获得性等因素影响。全球运动刺激的这种变化通过激素控制和局部变构调节对关键酶和运输蛋白产生调节作用。鉴于高CHO供给量对促进运动成绩的作用已经得到了充分的证明，优秀耐力运动员通常被建议在高强度训练或比赛之前、期间和之后确保高CHO供给量。尽管如此，认识到糖原颗粒不仅仅是一个简单的燃料储存，现在也被认为糖原是调节氧化表型的分子细胞信号通路的有力调节器。因此，刻意训练和低CHO可用性的概念现在在体育界得到了越来越多的欢迎。在这篇综述中，我们概述了运动中CHO代谢的调节控制(特别强调肌糖原利用)，以讨论高CHO利用率和低CHO利用率分别对调节运动成绩和训练适应的影响。
Since the introduction of the muscle biopsy technique in the late 1960s, our understanding of the regulation of muscle glycogen storage and metabolism has advanced considerably. Muscle glycogenolysis and rates of carbohydrate (CHO) oxidation are affected by factors such as exercise intensity, duration, training status and substrate availability. Such changes to the global exercise stimulus exert regulatory effects on key enzymes and transport proteins via both hormonal control and local allosteric regulation. Given the well-documented effects of high CHO availability on promoting exercise performance, elite endurance athletes are typically advised to ensure high CHO availability before, during and after high-intensity training sessions or competition. Nonetheless, in recognition that the glycogen granule is more than a simple fuel store, it is now also accepted that glycogen is a potent regulator of the molecular cell signaling pathways that regulate the oxidative phenotype. Accordingly, the concept of deliberately training with low CHO availability has now gained increased popularity amongst athletic circles. In this review, we present an overview of the regulatory control of CHO metabolism during exercise (with a specific emphasis on muscle glycogen utilization) in order to discuss the effects of both high and low CHO availability on modulating exercise performance and training adaptations, respectively.
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影响因子：
5.5
作者：
Chambers, E. S.;Bridge, M. W.;Jones, D. A.
通讯作者：
Jones, D. A.
DOI：
10.1016/j.bbrc.2006.02.057
发表时间：
2006-04-14
影响因子：
3.1
作者：
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通讯作者：
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DOI：
10.1152/ajpendo.1997.273.2.e268
发表时间：
1997-08-01
影响因子：
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作者：
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DOI：
10.1152/ajpendo.1999.277.1.e81
发表时间：
1999-07-01
影响因子：
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作者：
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影响因子：
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作者：
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