Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study.
Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study.
复制标题
日本老年人的脑白质病变与认知功能和情绪的关联：一项基于人群的研究。
DOI：
10.1002/brb3.315
复制
发表时间：
2015-03
影响因子：
3.1
通讯作者：
Nakashima, Kenji
中科院分区：
文献类型：
--
作者：
Yamawaki, Mika;Wada-Isoe, Kenji;Yamamoto, Mikie;Nakashita, Satoko;Uemura, Yusuke;Takahashi, Yoshimitsu;Nakayama, Takeo;Nakashima, Kenji
关键词：
确定区域性白色病变（WML）、生活方式因素与认知、运动功能和情绪之间的关系。2009年10月1日，对居住在天町的65岁以上的老年人进行了脑MRI、血液检查、帕金森病统一评定量表、简易精神状态检查、老年抑郁量表等综合评价。使用Fazekas评分，根据室周高信号（PVH）和深部白色物质高信号（DWMH）的严重程度对参与者进行分类。在900名合格参与者中，688名（76.4%）入组，包括303名男性。重度PVH的重要预测因素是年龄较大、低密度脂蛋白胆固醇（LDL-C）水平较低、血压（BP）升高、脑梗死和目前不饮酒。严重DWMH的重要预测因素是年龄较大，1，5-脱水葡萄糖醇（1，5-AG）水平较低，血压升高，脑梗死，目前没有饮酒。较高的认知功能与年龄较小、女性、轻度DWMH、受教育年限较长和高密度脂蛋白胆固醇水平较高相关。抑郁症状与较低的1，5-AG水平、较低的LDL-C水平、中度至重度PVH和当前无饮酒相关。老年人白色病变与高血压、糖耐量减低有关。WML的严重程度与认知功能和情绪有关。
To determine the relationships between regional white matter lesions (WMLs), lifestyle factors, and cognitive, motor function and mood. A comprehensive evaluation, including brain MRI, blood tests, the Unified Parkinson's Disease Rating Scale, the Mini Mental State Examination, and the Geriatric Depression Scale, was performed for people aged 65 years or older living in Ama-cho on October 1, 2009. Participants were classified by severity of periventricular hyperintensities (PVH) and deep white matter hyperintensities (DWMH) using the Fazekas score. Of 900 eligible participants, 688 (76.4%) were enrolled, including 303 men. Significant predictors of severe PVH were older age, lower low-density lipoprotein cholesterol (LDL-C) levels, elevated blood pressure (BP), cerebral infarction, and no current alcohol use. Significant predictors of severe DWMH were older age, lower 1,5-anhydroglucitol (1,5-AG) levels, elevated BP, cerebral infarction, and no current alcohol use. Higher cognitive function was associated with younger age, female sex, mild DWMH, more years of education, and higher high-density lipoprotein cholesterol levels. Depressive symptoms were associated with lower 1,5-AG levels, lower LDL-C levels, moderate to severe PVH, and no current alcohol use. White matter lesions in elderly people were related to hypertension and impaired glucose tolerance. The severity of WMLs was associated with cognitive function and mood.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
8.3
作者：
Alvarez-Sabin, Jose;Huertas, Rafael;Montaner, Joan
通讯作者：
Montaner, Joan
影响因子：
17.7
作者：
Jorm, AF;Anstey, KJ;Sachdev, P
通讯作者：
Sachdev, P
影响因子：
9.9
作者：
Tirschwell, DL;Smith, NL;Psaty, BM
通讯作者：
Psaty, BM
影响因子：
8.3
作者：
Kapeller, P;Barber, R;Fazekas, F
通讯作者：
Fazekas, F