Learning about memory.
Learning about memory.
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学习记忆。
DOI：
10.1037/001590
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
B. Basden
中科院分区：
文献类型：
--
作者：
B. Basden
尽管CCR 5在免疫和HIV感染中的作用已被广泛研究，但其在神经元可塑性、学习和记忆中的作用尚不清楚。在这里，我们报告说，降低CCR 5的功能增加MAPK/CREB信号，长时程增强（LTP），和海马依赖性记忆的小鼠，而神经元CCR 5过度表达引起记忆缺陷。降低小鼠桶皮质中的CCR 5功能也导致增强的尖峰时间依赖性可塑性，因此，显着加速经验依赖性可塑性。这些结果表明，CCR 5是一个强大的可塑性和记忆抑制剂，CCR 5过度激活病毒蛋白可能有助于艾滋病毒相关的认知缺陷。与这一假设相一致，HIV V3肽引起LTP、信号传导和记忆缺陷，这些缺陷通过Ccr 5敲除或敲低来预防。总的来说，我们的研究结果表明，CCR 5在神经可塑性，学习和记忆中起着重要作用，并表明CCR 5在艾滋病毒引起的认知缺陷中发挥作用。与LTP实验的结果相同。一旦建立了记录，将灌注溶液转换为无镁的ACSF，并通过向浴溶液中加入20 mM CNQX来分离NMDA受体介导的反应。单一细胞外刺激以0.1 Hz递送。在建立稳定的基线后，停止刺激，并将10 mM MK-801冲洗到切片上10 min。
Although the role of CCR5 in immunity and in HIV infection has been studied widely, its role in neuronal plasticity, learning and memory is not understood. Here, we report that decreasing the function of CCR5 increases MAPK/CREB signaling, long-term potentiation (LTP), and hippocampus-dependent memory in mice, while neuronal CCR5 overexpression caused memory deficits. Decreasing CCR5 function in mouse barrel cortex also resulted in enhanced spike timing dependent plasticity and consequently, dramatically accelerated experience-dependent plasticity. These results suggest that CCR5 is a powerful suppressor for plasticity and memory, and CCR5 over-activation by viral proteins may contribute to HIV-associated cognitive deficits. Consistent with this hypothesis, the HIV V3 peptide caused LTP, signaling and memory deficits that were prevented by Ccr5 knockout or knockdown. Overall, our results demonstrate that CCR5 plays an important role in neuroplasticity, learning and memory, and indicate that CCR5 has a role in the cognitive deficits caused by HIV. were identical to those for the LTP experiments. Once the recordings were established the perfusion solution was switched to magnesium-free ACSF and an NMDA-receptor mediated response was isolated by the addition of 20 m M CNQX to the bath solution. Single extracellular stimuli were delivered at 0.1 Hz. After a stable baseline had been established, stimulation was halted and 10 m M MK-801 was washed onto the slice for 10 min.
影响因子：
56.9
作者：
McClearn, GE;Johansson, B;Plomin, R
通讯作者：
Plomin, R