Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder.
Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder.
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DOI：
10.1016/j.parkreldis.2016.03.006
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发表时间：
2016-06
影响因子：
4.1
通讯作者：
Weintraub D
中科院分区：
文献类型：
--
作者：
Chahine LM;Xie SX;Simuni T;Tran B;Postuma R;Amara A;Oertel WH;Iranzo A;Scordia C;Fullard M;Linder C;Purri R;Darin A;Rennert L;Videnovic A;Del Riva P;Weintraub D
认知功能下降在帕金森氏病(PD)中很常见，识别出这种疾病的最高风险是至关重要的。我们的目的是研究可能的快速眼动睡眠行为障碍(PRBD)对早期帕金森病认知减退率的影响，包括全局认知和特定认知领域。帕金森进展标记物倡议(PPMI)是一项针对帕金森病患者的多点国际研究，这些患者在登记时未接受治疗。采用快速眼动睡眠行为障碍问卷(RBDSQ)评定pRBD。使用蒙特利尔认知评估(MoCA)和认知组合在基线和年度对全球认知进行评估。采用线性混合效应模型检验认知变量变化率与pRBD(RBDQ≥6)之间的关系。年龄、性别、受教育年限以及基线运动和认知分数被包括为协变量。基线样本包括423名帕金森病患者，平均年龄61.7岁，其中65.5%为男性。389名、366名和196名参与者分别在1年、2年和3年的随访中获得了数据。基线时108例(25.5%)可能发生RBD。在多变量分析中，基线的RBD与更大的年递减率相关(β=−0.34，95%CI−0.54，−0.13，p<；0.001)，符号数字模式测验(β=−0.69，95%CI−1.3，−0.09，p=0.024)，以及霍普金斯语言学习测验修订的延迟自由回忆(β=−0.21，95%CI−0.41，−0.013，p=0.037)。可能的RBD在早期帕金森病中很常见，并预测未来的认知能力下降，特别是在注意力和记忆领域。
Cognitive decline is common in Parkinson’s disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. Parkinson’s Progression Markers Initiative (PPMI) is a multi-site, international study of PD patients untreated at enrollment. pRBD was assessed with the REM sleep behavior disorder questionnaire (RBDSQ). Global cognition was assessed at baseline and annually using the Montreal Cognitive Assessment (MoCA) and a cognitive battery. Linear mixed effects models were used to examine the relationship between pRBD (RBDSQ ≥ 6) and rate of change in cognitive variables. Age, sex, years of education, and baseline motor and cognitive scores were included as covariates. The baseline sample consisted of 423 individuals with PD, mean age 61.7 years and 65.5% male. Data was available on 389, 366, and 196 participants at 1-year, 2-year, and 3-year follow-up respectively. Possible RBD occurred in 108 (25.5%) at baseline. In multivariate analyses, baseline RBD was associated with greater annual rate of decline in MoCA score (β = −0.34, 95%CI −0.54, −0.13, p < 0.001), Symbol Digit Modalities Test (β = −0.69, 95%CI −1.3, −0.09, p = 0.024), and Hopkins Verbal Learning Test-Revised, delayed free recall (β = −0.21, 95%CI −0.41, −0.013, p = 0.037). Possible RBD is common in early PD and predicts future cognitive decline, particularly in attention and memory domains.
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影响因子：
8.6
作者：
Postuma, Ronald B.;Bertrand, Josie-Anne;Gagnon, Jean-Francois
通讯作者：
Gagnon, Jean-Francois
影响因子：
9.9
作者：
de la Riva, Patricia;Smith, Kara;Weintraub, Daniel
通讯作者：
Weintraub, Daniel
影响因子：
9.9
作者：
Sixel-Doering, Friederike;Trautmann, Ellen;Trenkwalder, Claudia
通讯作者：
Trenkwalder, Claudia
DOI：
10.1111/j.1532-5415.2005.53221.x
发表时间：
2005-04-01
影响因子：
6.3
作者：
Nasreddine, ZS;Phillips, NA;Chertkow, H
通讯作者：
Chertkow, H
影响因子：
6.7
作者：
Marek, Kenneth;Jennings, Danna;Lasch, Shirley;Siderowf, Andrew;Tanner, Caroline;Simuni, Tanya;Coffey, Chris;Kieburtz, Karl;Flagg, Emily;Chowdhuty, Sohini;Poewe, Werner;Mollenhauer, Brit;Sherer, Todd;Frasier, Mark;Meunier, Claire;Rudolph, Alice;Casaceli, Cindy;Seibyl, John;Mendick, Susan;Schuff, Norbert;Zhang, Ying;Toga, Arthur;Crawford, Karen;Ansbach, Alison;Piovella, Michele;Trojanowski, John;Shaw, Les;Singleton, Andrew;Hawkins, Keith;Eberling, Jamie;Brooks, Deborah;Russell, David;Leary, Laura;Factor, Stewart;Sommerfeld, Barbara;Hogarth, Penelope;Pighetti, Emily;Williams, Karen;Standaert, David;Guthrie, Stephanie;Hauser, Robert;Delgado, Holly;Jankovic, Joseph;Hunter, Christine;Stern, Matthew;Baochan Tran;Leverenz, Jim;Baca, Marne;Frank, Sam;Thomas, Cathi-Ann;Richard, Irene;Deeley, Cheryl;Rees, Linda;Sprenger, Fabienne;Lang, Elisabeth;Shill, Holly;Obradov, Sanja;Fernandez, Hubert;Winters, Adrienna;Berg, Daniela;Gauss, Katharina;Galasko, Douglas;Fontaine, Deborah;Mari, Zoltan;Gerstenhaber, Melissa;Brooks, David;Malloy, Sophie;Barone, Paolo;Longo, Katia;Comery, Tom;Ravina, Bernard;Grachev, Igor;Gallagher, Kim;Collins, Michelle;Widnell, Katherine L.;Ostrowizki, Suzanne;Fontoura, Paulo;La-Roche, Hoffmann;Ho, Tony;Luthman, Johan;van der Brug, Marcel;Reith, Alastair D.;Taylor, Peggy
通讯作者：
Taylor, Peggy