Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors.
Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors.
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DOI：
10.1007/s40519-023-01617-5
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发表时间：
2023-10-30
影响因子：
2.9
通讯作者：
Tang, Li-rong
中科院分区：
文献类型：
--
作者：
Wang, Jia-ni;Wang, Miao;Wu, Guo-wei;Li, Wei-hua;Lv, Zi-ling;Chen, Qian;Yang, Zheng-han;Li, Xiao-hong;Wang, Zhen-chang;Li, Zhan-jiang;Zhang, Peng;Tang, Li-rong
关键词：
神经性贪食症（BN）的特征是反复暴饮暴食和不适当的代偿行为。这项研究调查了BN患者静息状态下基于表面的神经活动的变化，并探讨了大脑活动与饮食行为之间的相关性。共纳入26例BN患者和28例健康对照。在Surfstat中进行大脑皮质活动的间接测量和功能连接（FC）分析。主成分分析（PCA）模型被用来捕捉BN组的行为问卷的共性。与健康对照组相比，BN组显示右侧上级顶叶（SPL）基于表面的二维区域均匀性降低。此外，BN组显示右侧SPL与双侧舌回之间的FC减少，右侧SPL与左侧尾状核和右侧壳核之间的FC增加。在FC-行为关联分析中，第二主成分（PC 2）与右侧SPL和左侧尾状核之间的FC呈负相关。第三主成分（PC 3）与右侧SPL和左侧舌回之间的FC呈负相关，与右侧SPL和右侧舌回之间的FC呈正相关。我们发现，在BN的全脑水平上，右SPL相对于特定的脑区域进行重组。此外，我们的研究结果表明大脑重组和适应不良的饮食行为之间存在相关性。这些发现可能为更好地理解BN的神经机制提供有用的信息。五、描述性研究。在线版本包含补充材料，可通过10.1007/s40519-023-01617-5获得。
Bulimia nervosa (BN) is characterized by recurrent binge-eating episodes and inappropriate compensatory behaviors. This study investigated alterations in resting-state surface-based neural activity in BN patients and explored correlations between brain activity and eating behavior. A total of 26 BN patients and 28 healthy controls were enrolled. Indirect measurement of cerebral cortical activity and functional connectivity (FC) analyses were performed in Surfstat. A principal component analysis (PCA) model was used to capture the commonalities within the behavioral questionnaires from the BN group. Compared with the healthy control group, the BN group showed decreased surface-based two-dimensional regional homogeneity in the right superior parietal lobule (SPL). Additionally, the BN group showed decreased FC between the right SPL and the bilateral lingual gyrus and increased FC between the right SPL and the left caudate nucleus and right putamen. In the FC–behavior association analysis, the second principal component (PC2) was negatively correlated with FC between the right SPL and the left caudate nucleus. The third principal component (PC3) was negatively correlated with FC between the right SPL and the left lingual gyrus and positively correlated with FC between the right SPL and the right lingual gyrus. We revealed that the right SPL undergoes reorganization with respect to specific brain regions at the whole-brain level in BN. In addition, our results suggest a correlation between brain reorganization and maladaptive eating behavior. These findings may provide useful information to better understand the neural mechanisms of BN. V, descriptive study. The online version contains supplementary material available at 10.1007/s40519-023-01617-5.
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影响因子：
5.3
作者：
Danner, Unna N.;Evers, Catharine;de Ridder, Denise T. D.
通讯作者：
de Ridder, Denise T. D.
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
影响因子：
2.8
作者：
Anderson, D A;Williamson, D A;Grieve, C O
通讯作者：
Grieve, C O
DOI：
10.1016/j.cppeds.2017.02.004
发表时间：
2017-04-01
影响因子：
1.6
作者：
Castillo, Marigold;Weiselberg, Eric
通讯作者：
Weiselberg, Eric
影响因子：
3.7
作者：
Molenberghs, Pascal;Mesulam, Marsel M.;Vandenberghe, Rik R. C.
通讯作者：
Vandenberghe, Rik R. C.