Fibrinogen, Fibrin, and Fibrin Degradation Products in COVID-19.
Fibrinogen, Fibrin, and Fibrin Degradation Products in COVID-19.
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DOI：
10.2174/1389450123666220826162900
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发表时间：
2022
影响因子：
3.2
通讯作者：
Flick, Matthew J.
中科院分区：
文献类型：
--
作者：
Kangro, Kadri;Wolberg, Alisa S. S.;Flick, Matthew J.
严重急性呼吸综合征冠状病毒-2 （SARS-CoV-2）是一种高致病性和高传染性的人类冠状病毒，是全球COVID-19大流行的病原体。COVID-19主要表现为呼吸道疾病，症状与病毒性肺炎一致，但COVID-19患者的其他器官系统（如肾脏、心脏、大脑）也可能出现紊乱。越来越多的数据表明，止血系统的显著激活是SARS-CoV-2感染的常见病理表现。凝血蛋白纤维蛋白原是最丰富的血浆蛋白之一。凝血激活后，中心凝血蛋白酶凝血酶将纤维蛋白原转化为纤维蛋白单体，纤维蛋白单体自组装形成基质，这是血凝块的主要结构成分。严重的COVID-19与循环纤维蛋白原的深度扰动、血管内和血管外纤维蛋白沉积和持久性以及纤维蛋白降解有关。目前的研究结果表明，高水平的纤维蛋白原和纤维蛋白降解产物d -二聚体是COVID-19预后不良的生物标志物。此外，体外和动物模型的新研究表明，纤维蛋白（原）在COVID-19发病机制中发挥了积极作用。在这里，我们回顾了目前关于纤维蛋白（原）和COVID-19的文献，包括可能的致病机制和以凝血和纤维蛋白（原）功能为中心的治疗策略。
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the highly pathogenic and highly transmissible human coronavirus that is the causative agent for the worldwide COVID-19 pandemic. COVID-19 manifests predominantly as a respiratory illness with symptoms consistent with viral pneumonia, but other organ systems (e.g., kidney, heart, brain) can also become perturbed in COVID-19 patients. Accumulating data suggest that significant activation of the hemostatic system is a common pathological manifestation of SARS-CoV-2 infection. The clotting protein fibrinogen is one of the most abundant plasma proteins. Following activation of coagulation, the central coagulation protease thrombin converts fibrinogen to fibrin monomers, which self-assemble to form a matrix, the primary structural component of the blood clot. Severe COVID-19 is associated with a profound perturbation of circulating fibrinogen, intra- and extravascular fibrin deposition and persistence, and fibrin degradation. Current findings suggest high levels of fibrinogen and the fibrin degradation product D-dimer are biomarkers of poor prognosis in COVID-19. Moreover, emerging studies with in vitro and animal models indicate fibrin(ogen) as an active player in COVID-19 pathogenesis. Here, we review the current literature regarding fibrin(ogen) and COVID-19, including possible pathogenic mechanisms and treatment strategies centered on clotting and fibrin(ogen) function.
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影响因子：
4.6
作者：
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