Comparison of the coagulopathies associated with COVID-19 and sepsis.
Comparison of the coagulopathies associated with COVID-19 and sepsis.
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DOI：
10.1002/rth2.12525
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发表时间：
2021-05
影响因子：
4.6
通讯作者：
Mackman N
中科院分区：
文献类型：
--
作者：
Campbell RA;Hisada Y;Denorme F;Grover SP;Bouck EG;Middleton EA;Wolberg AS;Rondina MT;Mackman N
2019冠状病毒病（COVID-19）与凝血激活有关，主要表现为血栓形成。脓毒症也与凝血激活有关，主要表现为弥散性血管内凝血。许多研究报告了COVID-19患者血浆D-二聚体水平升高，与严重程度、血栓形成和死亡率相关。本研究的目的是比较COVID-19或脓毒症患者血浆中循环细胞外囊泡组织因子（EVTF）活性和活性纤溶酶原激活物抑制剂1（派-1）的水平。我们测量了COVID-19患者（重症监护室[ICU]，N = 15;非ICU，N = 20）和脓毒症患者（N = 35）血浆样本中的d-二聚体、EVTF活性和活性派-1水平。与健康对照组相比，COVID-19患者的d-二聚体、EVTF活性和活性派-1水平显著较高。与健康对照组相比，脓毒症患者的D-二聚体和EVTF活性水平显著较高。与脓毒症患者相比，COVID-19患者的d-二聚体水平显著降低。ICU COVID-19患者的EVTF活性水平显著高于脓毒症患者。与脓毒症患者相比，COVID-19患者的活性派-1水平显著更高。高水平的EVTF活性和活性派-1可能会促进COVID-19患者的血栓形成，因为同时激活凝血和抑制纤维蛋白溶解。COVID-19患者体内高水平的活性派-1可能会限制交联纤维蛋白的纤溶酶降解和d-二聚体的释放。这可能解释了COVID-19患者的D-二聚体水平低于脓毒症患者。
Coronavirus disease 2019 (COVID‐19) is associated with activation of coagulation that mainly presents as thrombosis. Sepsis is also associated with activation of coagulation that mainly presents as disseminated intravascular coagulation. Many studies have reported increased levels of plasma d‐dimer in patients with COVID‐19 that is associated with severity, thrombosis, and mortality. The aim of this study was to compare levels of circulating extracellular vesicle tissue factor (EVTF) activity and active plasminogen activator inhibitor 1 (PAI‐1) in plasma from patients with COVID‐19 or sepsis. We measured levels of d‐dimer, EVTF activity, and active PAI‐1 in plasma samples from patients with COVID‐19 (intensive care unit [ICU], N = 15; and non‐ICU, N = 20) and patients with sepsis (N = 35). Patients with COVID‐19 had significantly higher levels of d‐dimer, EVTF activity, and active PAI‐1 compared with healthy controls. Patients with sepsis had significantly higher levels of d‐dimer and EVTF activity compared with healthy controls. Levels of d‐dimer were significantly lower in patients with COVID‐19 compared with patients with sepsis. Levels of EVTF activity were significantly higher in ICU patients with COVID‐19 compared with patients with sepsis. Levels of active PAI‐1 were significantly higher in patients with COVID‐19 compared with patients with sepsis. High levels of both EVTF activity and active PAI‐1 may promote thrombosis in patients with COVID‐19 due to simultaneous activation of coagulation and inhibition of fibrinolysis. The high levels of active PAI‐1 in patients with COVID‐19 may limit plasmin degradation of crosslinked fibrin and the release of d‐dimer. This may explain the lower levels of D‐dimer in patients with COVID‐19 compared with patients with sepsis.
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影响因子：
20.3
作者：
Brogren, H;Karlsson, L;Jern, S
通讯作者：
Jern, S
DOI：
10.1161/atvbaha.120.315338
发表时间：
2021-01
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Bouck EG;Denorme F;Holle LA;Middelton EA;Blair AM;de Laat B;Schiffman JD;Yost CC;Rondina MT;Wolberg AS;Campbell RA
通讯作者：
Campbell RA
影响因子：
4.6
作者：
Antoniak S
通讯作者：
Antoniak S
影响因子：
15.9
作者：
Chen, Guang;Wu, Di;Ning, Qin
通讯作者：
Ning, Qin
影响因子：
20.3
作者：
Manne, Bhanu Kanth;Denorme, Frederik;Campbell, Robert A.
通讯作者：
Campbell, Robert A.