Quantification of Myocardial Dosimetry and Glucose Metabolism Using a 17-Segment Model of the Left Ventricle in Esophageal Cancer Patients Receiving Radiotherapy
Quantification of Myocardial Dosimetry and Glucose Metabolism Using a 17-Segment Model of the Left Ventricle in Esophageal Cancer Patients Receiving Radiotherapy
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使用 17 节段左心室模型对接受放疗的食管癌患者的心肌剂量测定和葡萄糖代谢进行量化
DOI：
10.3389/fonc.2020.01599
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发表时间：
2020
影响因子：
4.7
通讯作者：
Yong Yin
中科院分区：
文献类型：
--
作者：
Xue Sha;G. Gong;Chunlei Han;Qingtao Qiu;Yong Yin
目的研究表明，正电子发射断层扫描（PET）显示心肌摄取18氟脱氧葡萄糖（FDG）增加可能是放射治疗（RT）后心肌损伤的一个指标。本研究的主要目的是量化心脏亚体积剂量测定和18F-FDG摄取肿瘤PET使用17段模型的左心室（LV），并确定剂量限制相关的变化，心脏18F-FDG摄取RT后。方法24例食管癌（EC）患者进行连续肿瘤18F-FDG PET/CT扫描在基线和RT后被纳入本研究。采用17节段模型对放射剂量和18F-FDG摄取进行定量分析。分析18F-FDG在基底部、中部和心尖部的摄取和剂量，以及不同剂量范围内18F-FDG摄取的变化。结果剂量分布不均匀，基底部平均剂量（18.36戈伊）高于中部和心尖部（分别为5.30和2.21戈伊）。第1、2、3和4段接受的剂量最高，均大于10戈伊。观察到三种模式的心肌18F-FDG摄取与放射剂量的RT前后：增加（5例），减少（13例），和没有变化（6例）。在配对分析中，RT后低剂量段（0-10戈伊和10-20戈伊）的18 F-FDG摄取分别减少了28.93%和12.12%，而高剂量段（20-30戈伊）增加了7.24%。结论胸段食管癌放射治疗后左室各节段放射治疗剂量差异较大，放射治疗后心肌18 F-FDG摄取增加，剂量大于20戈伊时心肌摄取增加。
Objective Previous studies have shown that increased cardiac uptake of 18F-fluorodeoxyglucose (FDG) on positron emission tomography (PET) may be an indicator of myocardial injury after radiotherapy (RT). The primary objective of this study was to quantify cardiac subvolume dosimetry and 18F-FDG uptake on oncologic PET using a 17-segment model of the left ventricle (LV) and to identify dose limits related to changes in cardiac 18F-FDG uptake after RT. Methods Twenty-four esophageal cancer (EC) patients who underwent consecutive oncologic 18F-FDG PET/CT scans at baseline and post-RT were enrolled in this study. The radiation dose and the 18F-FDG uptake were quantitatively analyzed based on a 17-segment model. The 18F-FDG uptake and doses to the basal, middle and apical regions, and the changes in the 18F-FDG uptake for different dose ranges were analyzed. Results A heterogeneous dose distribution was observed, and the basal region received a higher median mean dose (18.36 Gy) than the middle and apical regions (5.30 and 2.21 Gy, respectively). Segments 1, 2, 3, and 4 received the highest doses, all of which were greater than 10 Gy. Three patterns were observed for the myocardial 18F-FDG uptake in relation to the radiation dose before and after RT: an increase (5 patients), a decrease (13 patients), and no change (6 patients). In a pairing analysis, the 18F-FDG uptake after RT decreased by 28.93 and 12.12% in the low-dose segments (0–10 Gy and 10–20 Gy, respectively) and increased by 7.24% in the high-dose segments (20–30 Gy). Conclusion The RT dose varies substantially within LV segments in patients receiving thoracic EC RT. Increased 18F-FDG uptake in the myocardium after RT was observed for doses above 20 Gy.
DOI：
10.1016/j.ijrobp.2009.04.093
发表时间：
2010-01-01
影响因子：
7
作者：
Gagliardi, Giovanna;Constine, Louis S.;Marks, Lawrence B.
通讯作者：
Marks, Lawrence B.