Biomimetic microfluidic neuron for hybrid experiments

Biomimetic microfluidic neuron for hybrid experiments
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用于混合实验的仿生微流体神经元

DOI:
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发表时间:
2015
期刊:
影响因子:
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通讯作者:
T. Fujii
T. Fujii
中科院分区:
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文献类型:
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作者:
T. Levi;A. Mita;B. Ségard;Toshiyoshi Hiroshi;H. Fujita;T. Fujii

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本文报道了一种在神经形态工程中探索的新途径--利用微流控技术构建仿生人工神经元。这种装置能够模拟一个生物神经元的电活动。通常这些人工神经元是在硅中制造的,但这种设备可以取代电子设备,并解决大多数生物兼容性问题。该PDMS装置由用于细胞内和细胞外模拟的两个小室、不同的PDMS通道、用于正离子交换的选择性透膜、震动阀和用于记录膜电位的电极组成。我们得到了一个类似于生物神经元的电膜电位。
This paper reports a new way to explore in the neuromorphic engineering, the biomimetic artificial neuron using microfluidic techniques. This device is able to mimic the electrical activity of one biological neuron. Usually these artificial neurons are made in Silicon but this device could replace the electronic one and solve most of the issues of biocompatibility. This PDMS device is composed of two chambers for intra and extra-cellular modelling, different PDMS channels, selective permeable membrane for positive ionic exchange, quake valves and electrodes for recording the membrane potential. We obtain an electrical membrane potential similar to the biological neuron.
DOI: 10.1126/science.288.5463.113
发表时间: 2000-04-07
期刊: SCIENCE
影响因子: 56.9
作者:
Unger, MA;Chou, HP;Quake, SR
通讯作者: Quake, SR