The importance of the induction of gene expression and differentiation by cytotoxic chemotherapy.
The importance of the induction of gene expression and differentiation by cytotoxic chemotherapy.
复制标题
细胞毒性化疗诱导基因表达和分化的重要性。
作者：
S. Waxman
AbstractINTRODUCTION Cells cultured from animal and human tumors can be induced to differentiate by over 300 agents, including powerful nonphysiologic inducers such as polar solvents and Na-butyrate, and physiologic inducers such as hormones, regulatory peptides, retinoids, vitamin D3, proteases, hemin, and hypoxanthine (for review see Refs. 1,2). Differentiation can be defined as a coordinated genomic expression whose products are characteristic of a more defined cell lineage (e.g., differentiation of erythroleukemia cells is characterized by globin gene expression, followed by hemoglobin production). When differentiation of tumor cells is induced, it is often followed by reduced tumorigenicity due to a decrease in the proliferation rate. Agents that induce differentiation in leukemia, embryonal carcinoma, mammary carcinoma, and mouse melanoma cells in vitro, can also reduce tumor growth in vivo (for review see Refe 2,3). Anticancer treatments such as radiation, cytotoxic chemotherapeutic drugs, or inter...
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DOI：
10.1016/0065-2571(83)90005-5
发表时间：
1983
期刊：
Advances in enzyme regulation
影响因子：
--
作者：
Schwartz,EL;Ishiguro,K;Sartorelli,AC
通讯作者：
Sartorelli,AC
影响因子：
158.5
作者：
FEARON, ER;BURKE, PJ;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
影响因子：
--
作者：
Waxman,S;Scher,W;Scher,BM
通讯作者：
Scher,BM
原癌基因 c-myc、c-fos 和 c-fms 在急性髓细胞白血病诊断和缓解时的表达。
影响因子：
11.2
作者：
Preisler,HD;Kinniburgh,AJ;Wei-Dong,G;Khan,S
通讯作者：
Khan,S
蒽环类药物诱导 HL-60 人急性早幼粒细胞白血病细胞分化的构效关系。
影响因子：
11.2
作者：
Schwartz,EL;Sartorelli,AC
通讯作者：
Sartorelli,AC