Assessing the relationship between routine and schizophrenia symptoms with passively sensed measures of behavioral stability.

Assessing the relationship between routine and schizophrenia symptoms with passively sensed measures of behavioral stability.
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DOI:
10.1038/s41537-020-00123-2
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发表时间:
2020-11-23
期刊:
影响因子:
5.4
通讯作者:
Althoff T
Althoff T
中科院分区:
医学2区
文献类型:
--
作者:
He-Yueya J;Buck B;Campbell A;Choudhury T;Kane JM;Ben-Zeev D;Althoff T

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提高日常生活的稳定性与普通人群的福祉相关,并且通常是对精神分裂症等严重精神疾病患者进行行为干预的目标。在临床研究中,使用回顾性量表来评估行为稳定性受到限制,这种量表很容易出现报告偏差和记忆不准确的情况。移动无源传感器不易受到这些误差源的影响,已成为评估一系列人群行为模式的工具。本研究根据 61 名精神分裂症患者携带的被动传感系统一年内生成的数据开发并检验了行为稳定性指标。该指标(稳定性指数)与无源传感器的现有测量值正交,并且与最先进功能的预测性能相匹配。具体来说,社交活动(例如通话和消息)的稳定性越高,症状就越轻,而体力活动(例如静止)的稳定性越高,症状就越严重。这项研究为精神病人群中个体化的群体水平数据的预测价值提供了额外的支持。稳定性指数还提供了一个很有前途的工具,可以深入了解行为稳定性对精神分裂症谱系障碍的影响。
Increased stability in one’s daily routine is associated with well-being in the general population and often a goal of behavioral interventions for people with serious mental illnesses like schizophrenia. Assessing behavioral stability has been limited in clinical research by the use of retrospective scales, which are susceptible to reporting biases and memory inaccuracies. Mobile passive sensors, which are less susceptible to these sources of error, have emerged as tools to assess behavioral patterns in a range of populations. The present study developed and examined a metric of behavioral stability from data generated by a passive sensing system carried by 61 individuals with schizophrenia for one year. This metric—the Stability Index—appeared orthogonal from existing measures drawn from passive sensors and matched the predictive performance of state-of-the-art features. Specifically, greater stability in social activity (e.g., calls and messages) were associated with lower symptoms, and greater stability in physical activity (e.g., being still) appeared associated with elevated symptoms. This study provides additional support for the predictive value of individualized over population-level data in psychiatric populations. The Stability Index offers also a promising tool for generating insights about the impact of behavioral stability in schizophrenia-spectrum disorders.
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