Role of the Neuregulin Signaling Pathway in Nicotine Dependence and Co-morbid Disorders.
Role of the Neuregulin Signaling Pathway in Nicotine Dependence and Co-morbid Disorders.
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DOI：
10.1016/bs.irn.2015.07.006
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发表时间：
2015
影响因子：
--
通讯作者：
Turner JR
中科院分区：
文献类型：
--
作者：
Fisher ML;Loukola A;Kaprio J;Turner JR
吸烟目前是美国可预防死亡的主要原因，每年在全世界造成400多万人死亡。因此，在靶向戒烟的治疗方面存在巨大的临床未满足的需求。当检查吸烟者与精神疾病共病时，这一点更加明显，因为这一人群的吸烟率比一般人群高约4倍。检查共同的遗传和分子信号传导途径，影响吸烟行为和精神疾病，将导致更好地了解共病疾病和新疗法的潜在发展。研究表明，神经调节蛋白信号通路与许多精神疾病的病理生理学有关。此外，最近的研究也表明了神经调节蛋白信号通路与吸烟行为之间的关联。本文概述了神经调节蛋白信号通路的基本机制，以及如何利用它来治疗尼古丁依赖和精神疾病的精确医学方法。
Smoking is currently the leading cause of preventable death in the United States and is responsible for over four million deaths annually worldwide. Therefore, there is a vast clinical unmet need with regards to therapeutics targeting smoking cessation. This is even more apparent when examining smokers co-morbid with psychiatric illness, as rates of smoking in this population are ~4× higher than in the general population. Examining common genetic and molecular signaling pathways impinging upon both smoking behavior and psychiatric illness will lead to a better understanding of co-morbid disorders and potential development of novel therapeutics. Studies have implicated the Neuregulin Signaling Pathway in the pathophysiology of a number of psychiatric illnesses. Additionally, recent studies have also shown an association between the Neuregulin Signaling Pathway and smoking behaviors. This review outlines basic mechanisms of the Neuregulin Signaling Pathway and how it may be exploited for precision medicine approaches in treating nicotine dependence and mental illness.
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影响因子：
7.8
作者：
Bao, JX;Wolpowitz, D;Role, LW;Talmage, DA
通讯作者：
Talmage, DA
遗传学。人类变化项目。
DOI：
10.1126/science.1167363
发表时间：
2008-11-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cotton RG;Auerbach AD;Axton M;Barash CI;Berkovic SF;Brookes AJ;Burn J;Cutting G;den Dunnen JT;Flicek P;Freimer N;Greenblatt MS;Howard HJ;Katz M;Macrae FA;Maglott D;Möslein G;Povey S;Ramesar RS;Richards CS;Seminara D;Smith TD;Sobrido MJ;Solbakk JH;Tanzi RE;Tavtigian SV;Taylor GR;Utsunomiya J;Watson M
通讯作者：
Watson M
影响因子：
6.6
作者：
Braff, David L.;Freedman, Robert;Gottesman, Irving I.
通讯作者：
Gottesman, Irving I.
影响因子：
9.8
作者：
Gurling, HMD;Kalsi, G;Curtis, D
通讯作者：
Curtis, D
影响因子：
17.7
作者：
Faraone, Stephen V.;Hwu, Hai-Gwo;Tsuang, Ming T.
通讯作者：
Tsuang, Ming T.