Alcohol impairs brain reactivity to explicit loss feedback.
Alcohol impairs brain reactivity to explicit loss feedback.
复制标题
DOI：
10.1007/s00213-011-2323-3
复制
发表时间：
2011-11
影响因子：
3.4
通讯作者：
Bernat EM
中科院分区：
文献类型：
--
作者：
Nelson LD;Patrick CJ;Collins P;Lang AR;Bernat EM
酒精会损害大脑对表现错误的检测，错误相关负性（ERN）减弱就证明了这一点，ERN是一种事件相关电位（ERP），被认为反映了监控人行为的大脑系统。然而，目前尚不清楚酒精是否会损害更广泛的情况下的绩效监控能力，包括那些需要外部反馈的情况。本研究试图确定与酒精相关的监测缺陷是否特定于内部错误识别（由 ERN 反映），或者也发生在外部提示环境中。我们评估了饮酒对反馈相关消极性 (FRN) 的影响，这种 ERP 被认为与 ERN 具有类似的过程，但由环境中的负面绩效反馈引发。在随机分配饮酒（n = 37；平均峰值 BAC = 0.087 g/100 ml，根据呼吸酒精采样估计）或安慰剂饮料（n = 42）的本科生样本中，在两项选择的赌博任务中测量了 ERP 对得失反馈的反应。使用时频分析来解析重叠的 theta-FRN 和 delta-P3，并阐明酒精对测量的影响。酒精中毒减弱了 theta-FRN 和 delta-P3 大脑对反馈的反应。损失反馈后的 theta-FRN 衰减比增益反馈更强。 theta-FRN 和 delta-P3 成分的减弱表明酒精普遍减弱了大脑对此任务中反馈的反应。损失试验后 theta-FRN 衰减更强，这与之前的 ERN 研究结果一致，表明酒精广泛损害大脑对不同环境下负面表现结果的识别。
lcohol impairs the brain’s detection of performance errors as evidenced by attenuated error-related negativity (ERN), an event-related potential (ERP) thought to reflect a brain system that monitors one’s behavior. However, it remains unclear whether alcohol impairs performance-monitoring capacity across a broader range of contexts, including those entailing external feedback. This study sought to determine whether alcohol-related monitoring deficits are specific to internal recognition of errors (reflected by the ERN) or occur also in external cuing contexts. We evaluated the impact of alcohol consumption on the feedback-related negativity (FRN), an ERP thought to engage a similar process as the ERN but elicited by negative performance feedback in the environment. In an undergraduate sample randomly assigned to drink alcohol (n=37; average peak BAC=0.087 g/100 ml, estimated from breath alcohol sampling) or placebo beverages (n =42), ERP responses to gain and loss feedback were measured during a two-choice gambling task. Time–frequency analysis was used to parse the overlapping theta-FRN and delta-P3 and clarified the effects of alcohol on the measures. Alcohol intoxication attenuated both the theta-FRN and delta-P3 brain responses to feedback. The theta-FRN attenuation was stronger following loss than gain feedback. Attenuation of both theta-FRN and delta-P3 components indicates that alcohol pervasively attenuates the brain’s response to feedback in this task. That theta-FRN attenuation was stronger following loss trials is consistent with prior ERN findings and suggests that alcohol broadly impairs the brain’s recognition of negative performance outcomes across differing contexts.
登录
查看更多内容
DOI：
10.1016/0013-4694(90)90138-a
发表时间：
1990-06-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
HEINZE, HJ;LUCK, SJ;HILLYARD, SA
通讯作者：
HILLYARD, SA
影响因子：
56.9
作者：
Gehring, WJ;Willoughby, AR
通讯作者：
Willoughby, AR
影响因子：
3
作者：
Bernat, Edward M.;Malone, Stephen M.;Iacono, William G.
通讯作者：
Iacono, William G.
影响因子：
8.2
作者：
GEHRING, WJ;GOSS, B;DONCHIN, E
通讯作者：
DONCHIN, E
影响因子：
3.7
作者：
Pailing, PE;Segalowitz, SJ
通讯作者：
Segalowitz, SJ