Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity.
Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity.
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作者：
分泌型 IgA (SIgA) 抗体代表抗原特异性免疫防御的第一道防线，保护粘膜表面免受环境病原体和抗原的侵害，并维持共生微生物群的稳态。聚合免疫球蛋白受体（pIgR）具有双重作用：将局部产生的二聚体IgA转运穿过粘膜上皮，并作为分泌成分（一种增强SIgA免疫功能的糖蛋白）的前体。宿主和微生物因素对 pIgR 表达和转胞吞作用的复杂调节经过微调，以优化 SIgA 在粘膜免疫中的作用。在类似于炎症性肠病的疾病状态下，这种调节网络的破坏可能会对粘膜稳态和全身后遗症产生深远的影响。未来对 pIgR 和 SIgA 功能和调节的研究可能为预防和治疗源自粘膜表面的感染性和炎症性疾病提供新的见解。
Secretory IgA (SIgA) antibodies represent the first line of antigen-specific immune defense protecting the mucosal surfaces against environmental pathogens and antigens, and maintaining homeostasis with the commensal microbiota. The polymeric immunoglobulin receptor (pIgR) has the dual role of transporting locally produced dimeric IgA across mucosal epithelia, and serving as the precursor of secretory component, a glycoprotein that enhances the immune functions of SIgA. The complex regulation of pIgR expression and transcytosis by host and microbial factors is finely tuned to optimize the role of SIgA in mucosal immunity. Disruption of this regulatory network in disease states similar to inflammatory bowel disease can result in profound consequences for mucosal homeostasis and systemic sequelae. Future research into the function and regulation of pIgR and SIgA may offer new insights into the prevention and treatment of infectious and inflammatory diseases that originate at mucosal surfaces.
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影响因子：
21.3
作者：
Su, Tao;Bryant, David M.;Luton, Frederic;Verges, Marcel;Ulrich, Scott M.;Hansen, Kirk C.;Datta, Anirban;Eastburn, Dennis J.;Burlingame, Alma L.;Shokat, Kevan M.;Mostov, Keith E.
通讯作者：
Mostov, Keith E.
影响因子：
3.8
作者：
Pal, K;Kaetzel, CS;Cuff, CF
通讯作者：
Cuff, CF
DOI：
10.1097/ta.0b013e31820c780e
发表时间：
2011-03-01
影响因子：
--
作者：
Diebel, Lawrence N.;Liberati, David M.
通讯作者：
Liberati, David M.
影响因子：
6
作者：
Wentworth, Christy C.;Jones, Rheinallt M.;Neish, Andrew S.
通讯作者：
Neish, Andrew S.
分泌Iga在肠道中的免疫和粘膜稳态中的复杂角色。
影响因子：
8
作者：
通讯作者：
--