Gut immune maturation depends on colonization with a host-specific microbiota.
Gut immune maturation depends on colonization with a host-specific microbiota.
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DOI：
10.1016/j.cell.2012.04.037
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发表时间：
2012-06-22
期刊：
影响因子：
64.5
通讯作者：
Kasper DL
中科院分区：
文献类型：
--
作者：
Chung H;Pamp SJ;Hill JA;Surana NK;Edelman SM;Troy EB;Reading NC;Villablanca EJ;Wang S;Mora JR;Umesaki Y;Mathis D;Benoist C;Relman DA;Kasper DL
肠道微生物诱导宿主免疫成熟是宿主与微生物互利共生的典型例子。我们将小鼠微生物群（MMb）或人类微生物群（HMb）定植于无菌（GF）小鼠体内，以确定小肠免疫成熟是否依赖于共同进化的宿主特异性微生物群。MMb和HMb小鼠肠道中的细菌数量和门类丰度相似，但细菌种类不同，尤其是厚壁菌门。HMb小鼠肠道内CD4 +和CD8 + T细胞水平较低，增殖的T细胞较少，树突状细胞数量少，且抗菌肽表达水平低——这些都是无菌小鼠的特征。大鼠微生物群也无法使小鼠肠道T细胞数量完全增加。将小鼠分节丝状菌（SFB）定植于无菌或HMb小鼠体内，可使T细胞数量部分恢复，这表明SFB和其他MMb微生物是小鼠免疫完全成熟所必需的。重要的是，MMb对沙门氏菌感染的防护作用优于HMb。宿主特异性微生物群似乎对健康的免疫系统至关重要。
Gut microbial induction of host immune maturation exemplifies host-microbe mutualism. We colonized germ-free (GF) mice with mouse microbiota (MMb) or human microbiota (HMb) to determine whether small intestinal immune maturation depends on a coevolved host-specific microbiota. Gut bacterial numbers and phylum abundance were similar in MMb and HMb mice, but bacterial species differed, especially the Firmicutes. HMb mouse intestines had low levels of CD4+ and CD8+ T cells, few proliferating T cells, few dendritic cells, and low antimicrobial peptide expression–all characteristics of GF mice. Rat microbiota also failed to fully expand intestinal T cell numbers in mice. Colonizing GF or HMb mice with mouse-segmented filamentous bacteria (SFB) partially restored T cell numbers, suggesting that SFB and other MMb organisms are required for full immune maturation in mice. Importantly, MMb conferred better protection against Salmonella infection than HMb. A host-specific microbiota appears to be critical for a healthy immune system.
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影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
6.4
作者：
Heczko, U;Abe, A;Finlay, BB
通讯作者：
Finlay, BB
DOI：
10.1084/jem.172.1.239
发表时间：
1990-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bandeira A;Mota-Santos T;Itohara S;Degermann S;Heusser C;Tonegawa S;Coutinho A
通讯作者：
Coutinho A
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer