Epigenetics in traditional chinese pharmacy: a bioinformatic study at pharmacopoeia scale.
Epigenetics in traditional chinese pharmacy: a bioinformatic study at pharmacopoeia scale.
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DOI：
10.1093/ecam/neq050
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Wang SC
中科院分区：
文献类型：
--
作者：
Hsieh HY;Chiu PH;Wang SC
表观遗传学是基因组区域的染色质结构的可遗传变化的现象，导致该区域在细胞有丝分裂中处于转录沉默或活跃状态。越来越多的证据已经证明了DNA甲基化和组蛋白修饰模式的改变的表型后果，这是两种研究得很好的表观遗传机制。因此，表观基因组代表了一个有趣的治疗靶点。中国传统医学（TCM）是一个治疗系统，已经通过中医学发展了2100多年，并且在一些远东亚洲人群中仍然是一种流行的替代医学。我们检索了包含48491种与表观遗传相关蛋白相互作用的化学物质的3294种中药，发现29.8%的中药主要通过与Polycomb基团和甲基CpG结合蛋白的相互作用来调节表观基因组和miRNA。我们分析了200个政府批准的中药配方（TCMF），发现其中有统计学意义的比例（99%）是表观基因组和miRNA相互作用的。结果表明，帝王蝶属药用植物的表观基因组与miRNA的相互作用最为显著。组蛋白修饰被TCMFs大量利用，其中许多是滋补的。此外，从表观遗传学的角度来看，助理药剂师最不像君主。我们量化了表观遗传学在中医处方中的作用，发现表观基因组和miRNA相互作用信息单独决定了20%的TCMFs的临床应用领域。我们的研究结果为表观基因组作为药物靶点的概念提供了进一步的支持，并为中药处方的设计提供了一套新的工具。
Epigenetics is a phenomenon of heritable changes in the chromatin structure of a genomic region, resulting in a transcriptional silent or active state of the region over cell mitosis. Mounting evidence has demonstrated phenotypic consequence of alternations in the patterns of DNA methylation and histone modifications, two of the well-studied epigenetic mechanisms. The epigenome thus represents an interesting therapeutic target. Traditional Chinese medicine (TCM) is a system of therapies that has developed through empiricism for over 2100 years and has remained a popular alternative medicine in some Far East Asian populations. We searched 3294 TCM medicinals (TCMMs) containing 48 491 chemicals for chemicals that interact with the epigenetics-related proteins and found that 29.8% of the TCMMs are epigenome- and miRNA-modulating via, mainly, interactions with Polycomb group and methyl CpG-binding proteins. We analyzed 200 government-approved TCM formulas (TCMFs) and found that a statistically significant proportion (99%) of them are epigenome- and miRNA-interacting. The epigenome and miRNA interactivity of the Monarch medicinals is found to be most prominent. Histone modifications are heavily exploited by the TCMFs, many of which are tonic. Furthermore, epigenetically, the Assistant medicinals least resemble the Monarch. We quantified the role of epigenetics in TCM prescription and found that epigenome- and miRNA-interaction information alone determined, to an extent of 20%, the clinical application areas of the TCMFs. Our results provide (i) a further support for the notion of the epigenomes as a drug target and (ii) a new set of tools for the design of TCM prescriptions.
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影响因子：
12.8
作者：
Hewagama A;Richardson B
通讯作者：
Richardson B
影响因子：
3.6
作者：
Baccarelli A;Bollati V
通讯作者：
Bollati V
DOI：
10.1073/pnas.0808830105
发表时间：
2008-10-21
影响因子：
11.1
作者：
Kim, Daniel H.;Saetrom, Pal;Rossi, John J.
通讯作者：
Rossi, John J.
DOI：
10.1093/ecam/nen083
发表时间：
2010-09
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Choi SH;Chang IM
通讯作者：
Chang IM
影响因子：
30.8
作者：
Fuks, F;Burgers, WA;Kouzarides, T
通讯作者：
Kouzarides, T