Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.
Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.
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DOI：
10.1038/ng.3644
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发表时间：
2016-10
期刊：
影响因子：
30.8
通讯作者：
Thomson, Nicholas R.
中科院分区：
文献类型：
--
作者：
Feasey, Nicholas A.;Hadfield, James;Keddy, Karen H.;Dallman, Timothy J.;Jacobs, Jan;Deng, Xiangyu;Wigley, Paul;Barquist, Lars Barquist;Langridge, Gemma C.;Feltwell, Theresa;Harris, Simon R.;Mather, Alison E.;Fookes, Maria;Aslett, Martin;Msefula, Chisomo;Kariuki, Samuel;Maclennan, Calman A.;Onsare, Robert S.;Weill, Francois-Xavier;Le Hello, Simon;Smith, Anthony M.;McClelland, Michael;Desai, Prerak;Parry, Christopher M.;Cheesbrough, John;French, Neil;Campos, Josefina;Chabalgoity, Jose A.;Betancor, Laura;Hopkins, Katie L.;Nair, Satheesh;Humphrey, Tom J.;Lunguya, Octavie;Cogan, Tristan A.;Tapia, Milagritos D.;Sow, Samba O.;Tennant, Sharon M.;Bornstein, Kristin;Levine, Myron M.;Lacharme-Lora, Lizeth;Everett, Dean B.;Kingsley, Robert A.;Parkhill, Julian;Heyderman, Robert S.;Dougan, Gordon;Gordon, Melita A.;Thomson, Nicholas R.
肠炎沙门氏菌存在一个流行病学悖论。在高收入环境中，它是家禽相关自限性小肠结肠炎流行的原因，而在撒哈拉以南非洲，它是侵袭性非伤寒沙门氏菌病的主要原因，且病死率很高。对来自 45 个国家的 675 个肠炎沙门氏菌分离株的全基因组序列分析揭示了肠炎沙门氏菌存在一个全球流行分支和两个新的肠炎沙门氏菌分支，每个分支在地理上仅限于非洲的不同地区。非洲分离株表现出基因组降解、一种新的原噬菌体库，并具有扩展的多药耐药性质粒。肠炎沙门氏菌是沙门氏菌血清型的另一个例子，它表现出生态位可塑性，具有独特的进化枝，使其成为与鸡蛋工业生产相关的胃肠炎以及非洲多重耐药性血流侵袭性感染的主要原因。
An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whilst in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case-fatality. Whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries reveals the existence of a global epidemic clade and two novel clades of S. Enteritidis that are each geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire and have an expanded, multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs, and of multidrug resistant, bloodstream invasive infection in Africa.
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影响因子：
4.2
作者：
Betancor L;Yim L;Fookes M;Martinez A;Thomson NR;Ivens A;Peters S;Bryant C;Algorta G;Kariuki S;Schelotto F;Maskell D;Dougan G;Chabalgoity JA
通讯作者：
Chabalgoity JA
影响因子：
168.9
作者：
Feasey, Nicholas A.;Dougan, Gordon;Kingsley, Robert A.;Heyderman, Robert S.;Gordon, Melita A.
通讯作者：
Gordon, Melita A.
影响因子：
168.9
作者：
Kotloff, Karen L.;Nataro, James P.;Levine, Myron M.
通讯作者：
Levine, Myron M.
影响因子：
11.8
作者：
Feasey, Nicholas A.;Masesa, Clemens;Gordon, Melita A.
通讯作者：
Gordon, Melita A.
影响因子：
6.4
作者：
Jones, Timothy F.;Ingram, L. Amanda;Angulo, Frederick J.
通讯作者：
Angulo, Frederick J.