Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in the United States: Living Density, Viral Load, and Disproportionate Impact on Communities of Color.
Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in the United States: Living Density, Viral Load, and Disproportionate Impact on Communities of Color.
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美国严重急性呼吸综合症冠状病毒2在美国的传播：生活密度，病毒负荷和对颜色社区的不成比例影响。
DOI：
10.1093/cid/ciab701
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发表时间：
2022-05-30
期刊：
影响因子：
--
通讯作者：
Lin JT
中科院分区：
文献类型：
--
作者：
Cerami C;Popkin-Hall ZR;Rapp T;Tompkins K;Zhang H;Muller MS;Basham C;Whittelsey M;Chhetri SB;Smith J;Litel C;Lin KD;Churiwal M;Khan S;Rubinstein R;Claman F;Mollan K;Wohl D;Premkumar L;Powers KA;Juliano JJ;Lin FC;Lin JT
家庭是严重急性呼吸综合征冠状病毒传播的热点。这项前瞻性研究截至2020年10月在北卡罗来纳州招募了100例2019年冠状病毒病（COVID-19）病例和208名家庭成员，其中44%为西班牙裔或非白人。在指标病例出现症状后的中位数6天内对住户进行登记。使用每周鼻拭子定量聚合酶链反应（第7、14、21天）或第28天的血清转化检测家庭中的继发性病例。排除基线时pcr阳性的73名家庭接触者，家庭接触者的二次发病率（SAR）为32%（103人中有33人；95%可信区间[CI]， 22%-44%）。大多数病例发生在第7天，之后的病例通过病毒测序确认为家庭获得性病例。同一家庭的感染者有相似的鼻咽病毒载量（类内相关系数= 0.45;95% CI, 0.23 - 0.62）。有二次传播的家庭的指数病例中位数病毒载量比无传播的家庭高1.4 log10 (P = 0.03)，并且居住密度更高（超过3人居住在少于6个房间；优势比为3.3；95% CI为1.02-10.9）。与白人家庭相比，少数族裔家庭更有可能经历高居住密度，并且有更高的突发感染风险（SAR, 51% vs 19%; P = 0.01）。在高接种率感染的情况下，家庭拥挤可能会放大COVID-19的传播，可能会对有色人种社区造成不成比例的影响。家庭是严重急性呼吸综合征冠状病毒传播的热点。在美国，在高接种率感染的情况下，家庭拥挤可能会放大COVID-19的传播，可能会对有色人种社区造成不成比例的影响。
Households are hot spots for severe acute respiratory syndrome coronavirus 2 transmission. This prospective study enrolled 100 coronavirus disease 2019 (COVID-19) cases and 208 of their household members in North Carolina though October 2020, including 44% who identified as Hispanic or non-White. Households were enrolled a median of 6 days from symptom onset in the index case. Incident secondary cases within the household were detected using quantitative polymerase chain reaction of weekly nasal swabs (days 7, 14, 21) or by seroconversion at day 28. Excluding 73 household contacts who were PCR-positive at baseline, the secondary attack rate (SAR) among household contacts was 32% (33 of 103; 95% confidence interval [CI], 22%–44%). The majority of cases occurred by day 7, with later cases confirmed as household-acquired by viral sequencing. Infected persons in the same household had similar nasopharyngeal viral loads (intraclass correlation coefficient = 0.45; 95% CI, .23–.62). Households with secondary transmission had index cases with a median viral load that was 1.4 log10 higher than those without transmission (P = .03), as well as higher living density (more than 3 persons occupying fewer than 6 rooms; odds ratio, 3.3; 95% CI, 1.02–10.9). Minority households were more likely to experience high living density and had a higher risk of incident infection than did White households (SAR, 51% vs 19%; P = .01). Household crowding in the context of high-inoculum infections may amplify the spread of COVID-19, potentially contributing to disproportionate impact on communities of color. Households are hot spots for severe acute respiratory syndrome coronavirus 2 transmission. In the United States, household crowding in the context of high-inoculum infections may amplify the spread of COVID-19, potentially contributing to disproportionate impact on communities of color.
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DOI：
10.1126/science.abe8499
发表时间：
2020-12-18
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Hou YJ;Chiba S;Halfmann P;Ehre C;Kuroda M;Dinnon KH 3rd;Leist SR;Schäfer A;Nakajima N;Takahashi K;Lee RE;Mascenik TM;Graham R;Edwards CE;Tse LV;Okuda K;Markmann AJ;Bartelt L;de Silva A;Margolis DM;Boucher RC;Randell SH;Suzuki T;Gralinski LE;Kawaoka Y;Baric RS
通讯作者：
Baric RS
影响因子：
6.4
作者：
Maltezou, Helena C.;Raftopoulos, Vasilios;Tsakris, Athanasios
通讯作者：
Tsakris, Athanasios
影响因子：
12.7
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Li, Zhengtu;Yi, Yongxiang;Ye, Feng
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Ye, Feng
DOI：
10.1093/cid/ciaa1558
发表时间：
2021-07-30
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Fung HF;Martinez L;Alarid-Escudero F;Salomon JA;Studdert DM;Andrews JR;Goldhaber-Fiebert JD;Stanford-CIDE Coronavirus Simulation Model (SC-COSMO) Modeling Group
通讯作者：
Stanford-CIDE Coronavirus Simulation Model (SC-COSMO) Modeling Group
DOI：
10.1016/s1473-3099(20)30985-3
发表时间：
2021-05
期刊：
The Lancet. Infectious diseases
影响因子：
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作者：
Marks M;Millat-Martinez P;Ouchi D;Roberts CH;Alemany A;Corbacho-Monné M;Ubals M;Tobias A;Tebé C;Ballana E;Bassat Q;Baro B;Vall-Mayans M;G-Beiras C;Prat N;Ara J;Clotet B;Mitjà O
通讯作者：
Mitjà O