The Household Secondary Attack Rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Rapid Review.
The Household Secondary Attack Rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Rapid Review.
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DOI：
10.1093/cid/ciaa1558
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发表时间：
2021-07-30
期刊：
影响因子：
--
通讯作者：
Stanford-CIDE Coronavirus Simulation Model (SC-COSMO) Modeling Group
中科院分区：
文献类型：
--
作者：
Fung HF;Martinez L;Alarid-Escudero F;Salomon JA;Studdert DM;Andrews JR;Goldhaber-Fiebert JD;Stanford-CIDE Coronavirus Simulation Model (SC-COSMO) Modeling Group
尽管抗击2019冠状病毒病（COVID-19）的大部分公共卫生工作都集中在公共场所的疾病控制策略上，但严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）在家庭内的传播仍然是一个重要问题。对家庭传播的性质和决定因素知之甚少。 为了解决这一差距，我们收集并分析了截至2020年9月2日来自10个国家（20291名家庭接触者）的22项已发表和预发表研究的数据。我们的目标是联合收割机估计的SARS-CoV-2家庭二次攻击率（SAR），并探讨家庭SAR的估计的变化。 家庭SAR的总体合并随机效应估计值为17.1%（95%置信区间[CI]，13.7-21.2%）。在研究水平，按检验频率（1次检验、2次检验、>2次检验）分层的随机效应荟萃回归分析中，SAR估计值分别为9.2%（95% CI，6.7-12.3%）、17.5%（95% CI，13.9-21.8%）和21.3%（95% CI，13.8-31.3%）。在老年人接触者和有症状病例的接触者中，家庭SAR往往较高。 这些发现表明，使用单一随访检测报告的SAR可能被低估，并且多次检测COVID-19病例的家庭接触者可能会增加识别继发病例的产量。
Although much of the public health effort to combat coronavirus disease 2019 (COVID-19) has focused on disease control strategies in public settings, transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within households remains an important problem. The nature and determinants of household transmission are poorly understood. To address this gap, we gathered and analyzed data from 22 published and prepublished studies from 10 countries (20 291 household contacts) that were available through 2 September 2020. Our goal was to combine estimates of the SARS-CoV-2 household secondary attack rate (SAR) and to explore variation in estimates of the household SAR. The overall pooled random-effects estimate of the household SAR was 17.1% (95% confidence interval [CI], 13.7–21.2%). In study-level, random-effects meta-regressions stratified by testing frequency (1 test, 2 tests, >2 tests), SAR estimates were 9.2% (95% CI, 6.7–12.3%), 17.5% (95% CI, 13.9–21.8%), and 21.3% (95% CI, 13.8–31.3%), respectively. Household SARs tended to be higher among older adult contacts and among contacts of symptomatic cases. These findings suggest that SARs reported using a single follow-up test may be underestimated, and that testing household contacts of COVID-19 cases on multiple occasions may increase the yield for identifying secondary cases.
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DOI：
10.1056/nejmoa0905498
发表时间：
2009-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cauchemez S;Donnelly CA;Reed C;Ghani AC;Fraser C;Kent CK;Finelli L;Ferguson NM
通讯作者：
Ferguson NM
影响因子：
11.8
作者：
Park, Shin Young;Kim, Young-Man;Jeong, Eun Kyeong
通讯作者：
Jeong, Eun Kyeong
影响因子：
28.2
作者：
Wang, Zhongliang;Ma, Wanli;Zhang, Ruiguang
通讯作者：
Zhang, Ruiguang
影响因子：
158.5
作者：
Ikematsu, Hideyuki;Hayden, Frederick G.;Uehara, Takeki
通讯作者：
Uehara, Takeki
影响因子：
56.3
作者：
Boehmer, Merle M.;Buchholz, Udo;Zapf, Andreas
通讯作者：
Zapf, Andreas