Impaired Langerhans cell migration in psoriasis.
Impaired Langerhans cell migration in psoriasis.
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DOI：
10.1084/jem.20052367
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发表时间：
2006-04-17
期刊：
影响因子：
--
通讯作者：
Griffiths CE
中科院分区：
文献类型：
--
作者：
Cumberbatch M;Singh M;Dearman RJ;Young HS;Kimber I;Griffiths CE
我们已经研究了银屑病是否与表皮朗格汉斯细胞（LC）功能的全身效应有关，特别是LC从皮肤的迁移。与正常皮肤相比，银屑病患者未受累皮肤表皮LCs的频率和形态均正常。然而，这些细胞对通常诱导迁移的刺激（化学过敏原、肿瘤坏死因子α [TNF-α]和白细胞介素-1 β [IL-1β]）的响应动员基本上不存在，尽管TNF-α和IL-1β治疗与患者和对照组的炎症反应相当。LC从未受累皮肤迁移的失败并不归因于动员所需的IL-1β或TNF-α受体表达的改变，也与诱导的皮肤细胞因子表达无关。虽然LC迁移/周转动力学改变的作用尚未被正式排除，但这些数据揭示了银屑病中LC功能的非常一致的减少，这可能在疾病发病机制中起决定性作用。
We have examined whether psoriasis is associated with systemic effects on epidermal Langerhans cell (LC) function and, specifically, the migration of LCs from the skin. Compared with normal skin, the frequency and morphology of epidermal LCs in uninvolved skin from patients with psoriasis was normal. However, mobilization of these cells in response to stimuli that normally induce migration (chemical allergen, tumor necrosis factor α [TNF-α], and interleukin-1β [IL-1β]) was largely absent, despite the fact that treatment with TNF-α and IL-1β was associated with comparable inflammatory reactions in patients and controls. The failure of LC migration from uninvolved skin was not attributable to altered expression of receptors for IL-1β or TNF-α that are required for mobilization, nor was there an association with induced cutaneous cytokine expression. Although a role for altered dynamics of LC migration/turnover has not been formally excluded, these data reveal a very consistent decrement of LC function in psoriasis that may play a decisive role in disease pathogenesis.
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