PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation.
PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation.
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DOI：
10.1371/journal.pone.0005874
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发表时间：
2009-06-11
期刊：
影响因子：
3.7
通讯作者：
Dinges DF
中科院分区：
文献类型：
--
作者：
Goel N;Banks S;Mignot E;Dinges DF
相对于 4 重复等位基因 (PER34/4)，昼夜节律基因 PERIOD3 (PER35/5) 的可变数目串联重复 (VNTR) 多态性 5 重复等位基因与特定昼夜节律阶段的认知能力下降有关，该认知下降是对一晚完全睡眠剥夺 (TSD) 的反应。 PER35/5 还与较高的睡眠稳态有关，这被认为是这种认知脆弱性的基础。迄今为止，还没有研究使用候选基因方法来调查对慢性部分睡眠剥夺 (PSD) 的反应，这种情况与 TSD 不同，是数百万人每天持续经历的一种情况。我们评估了 PER3 VNTR 多态性是否会导致 PSD 期间累积的神经行为缺陷和睡眠稳态反应。 PER35/5 (n = 14)、PER34/5 (n = 63) 和 PER34/4 (n = 52) 健康成年人（22-45 岁）表现出认知能力和生理警觉性大幅但相当的累积下降，并且在每晚睡眠时间限制为 4 小时的 5 晚睡眠期间累积睡意增加。这种影响伴随着所有组中每日受试者间变异性的增加。 PER3 基因型在习惯性睡眠、生理睡眠结构、昼夜节律阶段、生理嗜睡、认知表现或主观嗜睡方面在基线时没有显着差异，尽管在 PSD 期间，与 PER34/4 受试者相比，在非快速眼动睡眠中通过 EEG 慢波能量测量，PER35/5 受试者的睡眠稳态压力略有但可靠地升高。 PER3 基因型和等位基因频率在白种人和非裔美国人之间没有显着差异。 PER3 VNTR 多态性与 PSD 神经行为反应的个体差异无关，尽管它与 PSD 期间睡眠稳态反应的一项标志物有关。 PER3 基因型基线的可比性及其对睡眠限制的等效个体间脆弱性表明，PER3 不会导致慢性睡眠不足的神经行为影响。
The variable number tandem repeat (VNTR) polymorphism 5-repeat allele of the circadian gene PERIOD3 (PER35/5) has been associated with cognitive decline at a specific circadian phase in response to a night of total sleep deprivation (TSD), relative to the 4-repeat allele (PER34/4). PER35/5 has also been related to higher sleep homeostasis, which is thought to underlie this cognitive vulnerability. To date, no study has used a candidate gene approach to investigate the response to chronic partial sleep deprivation (PSD), a condition distinct from TSD and one commonly experienced by millions of people on a daily and persistent basis. We evaluated whether the PER3 VNTR polymorphism contributed to cumulative neurobehavioral deficits and sleep homeostatic responses during PSD. PER35/5 (n = 14), PER34/5 (n = 63) and PER34/4 (n = 52) healthy adults (aged 22–45 y) demonstrated large, but equivalent cumulative decreases in cognitive performance and physiological alertness, and cumulative increases in sleepiness across 5 nights of sleep restricted to 4 h per night. Such effects were accompanied by increasing daily inter-subject variability in all groups. The PER3 genotypes did not differ significantly at baseline in habitual sleep, physiological sleep structure, circadian phase, physiological sleepiness, cognitive performance, or subjective sleepiness, although during PSD, PER35/5 subjects had slightly but reliably elevated sleep homeostatic pressure as measured physiologically by EEG slow-wave energy in non-rapid eye movement sleep compared with PER34/4 subjects. PER3 genotypic and allelic frequencies did not differ significantly between Caucasians and African Americans. The PER3 VNTR polymorphism was not associated with individual differences in neurobehavioral responses to PSD, although it was related to one marker of sleep homoeostatic response during PSD. The comparability of PER3 genotypes at baseline and their equivalent inter-individual vulnerability to sleep restriction indicate that PER3 does not contribute to the neurobehavioral effects of chronic sleep loss.
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影响因子：
5.6
作者：
DOUGLASS, AB;BORNSTEIN, R;DEMENT, WC
通讯作者：
DEMENT, WC
影响因子：
4.4
作者：
Galliaudi, Elodie;Taillard, Jacques;Philip, Pierre
通讯作者：
Philip, Pierre
影响因子：
3.5
作者：
Ciarleglio CM;Ryckman KK;Servick SV;Hida A;Robbins S;Wells N;Hicks J;Larson SA;Wiedermann JP;Carver K;Hamilton N;Kidd KK;Kidd JR;Smith JR;Friedlaender J;McMahon DG;Williams SM;Summar ML;Johnson CH
通讯作者：
Johnson CH
影响因子：
2.2
作者：
AKERSTEDT, T;GILLBERG, M
通讯作者：
GILLBERG, M
DOI：
10.3758/bf03200977
发表时间：
1985-12-01
期刊：
BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS
影响因子：
--
作者：
DINGES, DF;POWELL, JW
通讯作者：
POWELL, JW