PP2A-C may be a promising candidate for postmortem interval estimation
PP2A-C may be a promising candidate for postmortem interval estimation
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PP2A-C 可能是死后间隔估计的有希望的候选者
DOI：
10.1007/s00414-020-02466-y
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发表时间：
2021-01
影响因子：
2.1
通讯作者：
Xinshe Liu
中科院分区：
文献类型：
--
作者：
Jing Wang;Gang Chen;Hongyan Qian;Qing Shang;Jing Xiao;Min Liang;Baoyao Gao;Tao Li;Xinshe Liu
确定死后间隔（PMI）是法医病理学中的一项重要任务。然而，一种在死亡后24小时至大约7天之间确定PMI的可靠方法尚未建立。先前的一项研究表明……（原文“subun”似乎不完整）
Determining the postmortem interval (PMI) is an important task in forensic pathology. However, a reliable means of determining the PMI between 24 h and approximately 7 days after death has not yet been established. A previous study demonstrated that subunit A of protein phosphatase 2A (PP2A-A) is a promising candidate to estimate the PMI during the first 96 h. However, more detailed work is still needed to investigate PP2A’s function in PMI estimation. PP2A is a serine/threonine phosphatase consisting of three subunits (PP2A-A, PP2A-B, and PP2A-C), and its activation is reflected by Tyr-307 phosphorylation of the catalytic subunit (P-PP2A-C). In this study, we speculated that the other two subunits of PP2A and the activation of PP2A may play different roles in estimating the PMI. For this purpose, mice were euthanized and stored at different temperatures (4, 15, and 25 °C). At each temperature, the musculus vastus lateralis was collected at different time points (0, 24, 48, and 96 h) to investigate the degradation of PP2A-B, PP2A-C, and P-PP2A-C (Tyr-307). Homocysteine (Hcy) was used to establish a hyperhomocysteinemia animal model to explore the effects of plasma Hcy on PMI estimation. The data showed not only that PP2A-C was more stable than PP2A-B, but also that it was not affected by homocysteine (Hcy). These characteristics make PP2A-C a promising candidate for short-term (24 h to 48 h) PMI estimation.
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影响因子：
2.1
作者：
Ehrenfellner B;Zissler A;Steinbacher P;Monticelli FC;Pittner S
通讯作者：
Pittner S
DOI：
10.1097/00005072-197603000-00005
发表时间：
1976-03
影响因子：
3.2
作者：
K. Ansari;A. Rand;H. Hendrickson;M. Bentley
通讯作者：
K. Ansari;A. Rand;H. Hendrickson;M. Bentley
DOI：
10.1111/febs.13573
发表时间：
2016-03
期刊：
The FEBS journal
影响因子：
--
作者：
Sangodkar J;Farrington CC;McClinch K;Galsky MD;Kastrinsky DB;Narla G
通讯作者：
Narla G
影响因子：
2.1
作者：
Zissler A;Ehrenfellner B;Foditsch EE;Monticelli FC;Pittner S
通讯作者：
Pittner S
影响因子：
2.1
作者：
Poloz, Yekaterina O.;O'Day, Danton H.
通讯作者：
O'Day, Danton H.