Poor glycemic control is associated with low BMD detected in premenopausal women with type 1 diabetes.
Poor glycemic control is associated with low BMD detected in premenopausal women with type 1 diabetes.
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DOI：
10.1007/s00198-008-0763-3
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发表时间：
2009-06
影响因子：
4
通讯作者：
Palta, M.
中科院分区：
文献类型：
--
作者：
Danielson, K. K.;Elliott, M. E.;LeCaire, T.;Binkley, N.;Palta, M.
低骨密度和骨折可能是1型糖尿病的并发症。我们试图确定骨转换和血糖控制在低骨密度病因中的作用。来自威斯康星州糖尿病登记研究的绝经前妇女和匹配的对照组(n=75对)进行了比较。测量足跟和前臂骨密度，并测量髋部和脊柱骨密度。测定骨形成指标(骨钙素)、骨吸收指标(NTX)和血糖控制指标(HbA1c)。年龄在18-50岁之间，平均28岁，97%是非西班牙裔白人。在患有糖尿病的女性中，平均病程为16年，目前的HbA1c为8%。与对照组相比，糖尿病妇女既往骨折患病率高(37%比24%)，年龄组骨密度低(跟或前臂：49%比31%)，跟跟和前臂骨密度低，骨钙素水平低。NTX水平相似，表明分离的营业额有利于再吸收。血糖控制不良与除脊柱外的所有骨部位骨密度低、骨钙素和NTX水平低有关。优化的血糖控制可以预防1型糖尿病患者的低骨密度和骨转换改变，并降低骨折风险。
Low BMD and fracture may be complications of type 1 diabetes. We sought to determine the roles of bone turnover and glycemic control in the etiology of low BMD. Premenopausal women from the Wisconsin Diabetes Registry Study and matched controls were compared (n=75 pairs). Heel and forearm BMD were measured, and hip and spine BMD were measured in a subset. Markers of bone formation (osteocalcin) and resorption (NTx), and glycemic control (HbA1c) were determined. Age ranged from 18–50 years with a mean of 28, and 97% were Non-Hispanic white. Among women with diabetes, mean disease duration was 16 years and current HbA1c was 8%. Compared to controls, women with diabetes had a high prevalence of previous fracture (37% vs. 24%) and low BMD for age (heel or forearm: 49% vs. 31%), low heel and forearm BMD, and low osteocalcin levels. Levels of NTx were similar, suggesting uncoupled turnover favoring resorption. Poor glycemic control was associated with low BMD at all bone sites except the spine, and with low osteocalcin and NTx levels. Optimal glycemic control may prevent low BMD and altered bone turnover in type 1 diabetes, and decrease fracture risk.
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影响因子：
4
作者：
EASTELL, R;ROBINS, SP;RUSSELL, RGG
通讯作者：
RUSSELL, RGG
影响因子：
64.5
作者：
Lee, Na Kyung;Sowa, Hideaki;Karsenty, Gerard
通讯作者：
Karsenty, Gerard
影响因子：
6.2
作者：
Pasco, JA;Henry, MJ;Nicholson, GC
通讯作者：
Nicholson, GC
影响因子：
8.2
作者：
Matsushima, M;LaPorte, RE;Tajima, N
通讯作者：
Tajima, N
影响因子：
5.1
作者：
Moyer-Mileur, LJ;Dixon, SB;Murray, MA
通讯作者：
Murray, MA