Wound healing in development.
Wound healing in development.
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DOI：
10.1002/bdrc.21017
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发表时间：
2012-09
影响因子：
--
通讯作者：
Tuan, Tai-Lan
中科院分区：
文献类型：
--
作者：
Lee, Yun-Shain;Wysocki, Annette;Warburton, David;Tuan, Tai-Lan
伤口愈合是有机体保护自身免受伤害的固有能力。累积的证据表明，愈合过程模式胚胎形态发生，并可能导致器官再生或疤痕——与发育阶段或年龄相关的现象。皮肤是最大的器官。其形态发生和修复机制已被广泛研究，不仅因为其易于接近和观察的解剖位置，还因为其迷人的结构和重要功能。因此，本综述将重点关注使用皮肤作为模型器官，以阐明对哺乳动物发育调节的伤口愈合机制的新见解，特别强调 Wnt 信号通路的作用及其与 TGF-β 信号传导的串扰。讨论了其他器官研究的相关信息（如果适用），并展望了这些知识和新兴概念对再生医学的临床影响。
Wound healing is the inherent ability of an organism to protect itself against injuries. Cumulative evidence indicates that the healing process patterns embryonic morphogenesis and may result in either organ regeneration or scarring – phenomena that are developmental stage-or age-dependent. Skin is the largest organ. Its morphogenesis and repair mechanisms have been studied extensively due not only to its anatomical location, which allows easy access and observation, but also its captivating structure and vital function. Thus, this review will focus on using skin as a model organ to illustrate new insights into the mechanisms of wound healing that are developmentally regulated in mammals, with special emphasis on the roles of Wnt signaling pathways and their crosstalk with TGF-β signaling. Relevant information from studies of other organs is discussed where it applies, and the clinical impact from such knowledge and emerging concepts on regenerative medicine are also discussed in perspective.
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影响因子：
10.3
作者：
Akiyama, M;Matsuo, I;Shimizu, H
通讯作者：
Shimizu, H
DOI：
10.1073/pnas.102657399
发表时间：
2002-05-14
影响因子：
11.1
作者：
Cheon, SS;Cheah, AYL;Alman, BA
通讯作者：
Alman, BA
影响因子：
5
作者：
Cheon, S;Poon, R;Alman, BA
通讯作者：
Alman, BA
DOI：
10.1161/atvbaha.107.153668
发表时间：
2007-12-01
影响因子：
8.7
作者：
Al-Aly, Ziyad;Shao, Jian-Su;Towler, Dwight A.
通讯作者：
Towler, Dwight A.
影响因子：
6
作者：
Eming, Sabine A.;Werner, Sabine;Roers, Axel
通讯作者：
Roers, Axel