Microvascular Dysfunction as a Systemic Disease: A Review of the Evidence.
Microvascular Dysfunction as a Systemic Disease: A Review of the Evidence.
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DOI：
10.1016/j.amjmed.2022.04.006
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发表时间：
2022-09
影响因子：
5.9
通讯作者：
Keeley, Ellen C.
中科院分区：
文献类型：
--
作者：
Feuer, Daniel S.;Handberg, Eileen M.;Mehrad, Borna;Wei, Janet;Merz, C. Noel Bairey;Pepine, Carl J.;Keeley, Ellen C.
微血管功能障碍描述了一系列不同的病症，包括血管破坏、异常血管反应性、原位血栓形成和纤维化，其最终导致组织损伤和进行性器官衰竭。微血管功能障碍具有广泛的临床表现，从缺血性心脏病到肾衰竭、中风、失明、肺动脉高压和痴呆。一个有趣的统一假设表明，特定器官的微血管功能障碍是一种全身性疾病的表现，这种疾病随着年龄的增长而增加，并被血管危险因素加速。研究影响脑、视网膜、肾、肺和心脏的一系列微血管疾病之间的关系可能会发现共同的病理机制，从而为新的治疗策略提供信息。我们回顾了支持MVD代表一个全球性病理过程的证据。我们的重点是报告心脏与大脑、肾脏、视网膜和肺同时发生微血管功能障碍的研究。
Microvascular dysfunction describes a varied set of conditions which includes vessel destruction, abnormal vasoreactivity, in situ thrombosis, and fibrosis which ultimately results in tissue damage and progressive organ failure. Microvascular dysfunction has a wide array of clinical presentations, ranging from ischemic heart disease to renal failure, stroke, blindness, pulmonary arterial hypertension, and dementia. An intriguing unifying hypothesis suggests that microvascular dysfunction of specific organs is an expression of a systemic illness that worsens with age and is accelerated by vascular risk factors. Studying relationships across a spectrum of microvascular diseases affecting the brain, retina, kidney, lung, and heart may uncover shared pathologic mechanisms that could inform novel treatment strategies. We review the evidence that supports the notion that MVD represents a global pathologic process. Our focus is on studies reporting concomitant microvascular dysfunction of the heart with that of the brain, kidney, retina, and lung.
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影响因子：
24
作者：
Del Buono MG;Montone RA;Camilli M;Carbone S;Narula J;Lavie CJ;Niccoli G;Crea F
通讯作者：
Crea F
影响因子：
24
作者：
Cheung, Ning;Bluemke, David A.;Wong, Tien Yin
通讯作者：
Wong, Tien Yin
影响因子：
3.2
作者：
Fujii, Hideki;Takiuchi, Shin;Fukagawa, Masafumi
通讯作者：
Fukagawa, Masafumi
影响因子：
5.3
作者：
Arbel, Yaron;Sternfeld, Amir;Finkelstein, Ariel
通讯作者：
Finkelstein, Ariel
影响因子：
5.4
作者：
Ahmad A;Corban MT;Toya T;Sara JD;Lerman B;Park JY;Lerman LO;Lerman A
通讯作者：
Lerman A