The effect of iron depletion on chronic hepatitis C virus infection.

The effect of iron depletion on chronic hepatitis C virus infection.
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DOI:
10.1007/s12072-008-9076-z
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发表时间:
2008-09
影响因子:
6.6
通讯作者:
Lippi, Giuseppe
Lippi, Giuseppe
中科院分区:
医学2区
文献类型:
--
作者:
Franchini, Massimo;Targher, Giovanni;Capra, Franco;Montagnana, Martina;Lippi, Giuseppe

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越来越多的证据表明,铁超载在慢性丙型肝炎病毒感染中起着重要的病理生理作用。本文讨论了铁过量导致慢性丙型肝炎患者肝损伤的机制,以及放血去铁术对生化和组织学结果的影响。最后,我们将重点放在减少铁对干扰素抗病毒治疗应答率的影响上。
Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemical and histological outcomes in patients with chronic HCV infection have been discussed in this review. Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy.
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