Quantitative correlation of breast tissue parameters using magnetic resonance and X-ray mammography.
Quantitative correlation of breast tissue parameters using magnetic resonance and X-ray mammography.
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DOI：
10.1038/bjc.1996.30
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发表时间：
1996-01
影响因子：
8.8
通讯作者：
Boyd, NF
中科院分区：
文献类型：
--
作者：
Graham, SJ;Bronskill, MJ;Byng, JW;Yaffe, MJ;Boyd, NF
以前的研究人员已经表明，由X射线乳房X光摄影确定的乳房内纤维腺组织的比例(百分比密度)与乳腺癌风险之间存在强烈的关联。在这项研究中，研究了42例无症状受试者乳腺组织的百分比密度与两个客观磁共振参数(相对含水量和平均T2弛豫时间)之间的定量相关性。使用新开发的快速技术，对包含相同的、具有代表性的两个乳房部分的感兴趣体积进行磁共振测量。每个受试者的X光乳房X光照片都被数字化并半自动分析，以确定百分比密度。相对含水率与百分密度呈极显著正相关(P<；0.0001)，平均T2值与百分密度呈显著负相关(P<；0.0001)。MR和X光参数也与乳腺癌的社会人口学和人体测量学危险因素相关(P<；0.05)。讨论了MR参数在评估乳腺癌风险和提供频繁的、非危险的乳腺实质监测方面的潜在用途。
Previous investigators have shown that there is a strong association between the fraction of fibroglandular tissue within the breast as determined by X-ray mammography (per cent density) and breast cancer risk. In this study, the quantitative correlation between per cent density and two objective magnetic resonance (MR) parameters of breast tissue, relative water content and mean T2 relaxation time, as investigated for 42 asymptomatic subjects. Using newly developed, rapid techniques MR measurements were performed on a volume-of-interest incorporating equal, representative portions of both breasts. X-ray mammograms of each subject were digitised and analysed semiautomatically to determine per cent density. Relative water content showed a strong positive correlation with per cent density (Pearson correlation coefficient rp = 0.79, P < 0.0001) and mean T2 value showed a strong negative correlation with per cent density (rp = -0.61, P < 0.0001). The MR and X-ray parameters were also associated with sociodemographic and anthropometric risk factors for breast cancer (P < 0.05). The potential use of MR parameters to assess risk of breast cancer and to provide a frequent, non-hazardous monitor of breast parenchyma is discussed.
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影响因子：
2.2
作者：
HORE, PJ
通讯作者：
HORE, PJ
影响因子：
5
作者：
SCHECHTER, MT;MILLER, AB;HOWE, GR
通讯作者：
HOWE, GR
DOI：
10.1093/jnci/87.9.670
发表时间：
1995-05-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BOYD, NF;BYNG, JW;YAFFE, MJ
通讯作者：
YAFFE, MJ
DOI：
10.1093/jnci/84.10.777
发表时间：
1992-05-20
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
POON, CS;BRONSKILL, MJ;BOYD, NF
通讯作者：
BOYD, NF
DOI：
10.1002/jmri.1880050613
发表时间：
1995-11-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
Graham, SJ;Stanchev, PL;Plewes, DB
通讯作者：
Plewes, DB