Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers.
Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers.
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DOI：
10.3390/ijms241512213
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发表时间：
2023-07-30
影响因子：
5.6
通讯作者：
Yang, Hongsheng
中科院分区：
文献类型：
--
作者：
Xing, Lili;Wang, Lingyu;Liu, Shilin;Sun, Lina;Wessel, Gary M.;Yang, Hongsheng
关键词：
仿刺参具有重要的营养和药用价值。不幸的是，我们对这种动物体内活性化学物质的来源知之甚少，但这些动物丰富的色素被认为以有趣的方式发挥作用，可用于临床和食品化学用途。在这里，我们发现了关键细胞群与基因活性预测的海参身体的颜色形态使用单细胞RNA-seq。我们将这些细胞群称为黑素细胞和醌细胞，它们分别负责黑色素和醌色素的合成。我们整合了色素生物化学与转录谱的分析，以阐明棘皮动物中不同色素形成的分子调控机制。与每种颜色变体的相关色素分析相一致，这项研究扩展了我们对医学上重要的色素产生以及颜色变体的遗传机制的理解，并为探索生物活性物质和营养品领域的进展提供了深入的数据集。
The sea cucumber Apostichopus japonicus has important nutritional and medicinal value. Unfortunately, we know little of the source of active chemicals in this animal, but the plentiful pigments of these animals are thought to function in intriguing ways for translation into clinical and food chemistry usage. Here, we found key cell groups with the gene activity predicted for the color morphology of sea cucumber body using single-cell RNA-seq. We refer to these cell populations as melanocytes and quinocytes, which are responsible for the synthesis of melanin and quinone pigments, respectively. We integrated analysis of pigment biochemistry with the transcript profiles to illuminate the molecular mechanisms regulating distinct pigment formation in echinoderms. In concert with the correlated pigment analysis from each color morph, this study expands our understanding of medically important pigment production, as well as the genetic mechanisms for color morphs, and provides deep datasets for exploring advancements in the fields of bioactives and nutraceuticals.
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影响因子：
5
作者：
Kim, Eun-Hyun;Kim, Myo-Kyoung;Kim, Dong-Seok
通讯作者：
Kim, Dong-Seok
DOI：
10.1016/j.jprot.2007.12.013
发表时间：
2008-04-24
影响因子：
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影响因子：
5.5
作者：
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通讯作者：
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影响因子：
46.9
作者：
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