Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model.
Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model.
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DOI：
10.2174/157015911798376217
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发表时间：
2011-12
影响因子：
5.3
通讯作者：
Head E
中科院分区：
文献类型：
--
作者：
Martin SB;Dowling AL;Head E
Aged dogs and humans share complex cognitive and pathological responses to aging. Specifically, dogs develop Alzheimer’s Disease (AD) like beta-amyloid (Aβ) that are associated with cognitive deficits. Currently, therapeutic approaches to prevent AD are targeted towards reduced production, aggregation and increased clearance of Aβ. The current review discusses cognition and neuropathology of the aging canine model and how it has and continues to be useful in further understanding the safety and efficacy of potential AD prevention therapies targeting Aβ.
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