Color Doppler Imaging Study in Patients with Primary Open-Angle Glaucoma Treated with Timolol 0.5% and Carteolol 2%
Color Doppler Imaging Study in Patients with Primary Open-Angle Glaucoma Treated with Timolol 0.5% and Carteolol 2%
复制标题
颜色%20多普勒%20成像%20研究%20in%20患者%20with%20初级%20开角%20青光眼%20治疗%20with%20噻吗洛尔%200.5%%20和%20卡替洛尔%202%
DOI：
10.1177/112067210101100305
复制
发表时间：
2001
影响因子：
1.7
通讯作者：
L. Berardinelli
中科院分区：
文献类型：
--
作者：
P. Montanari;P. Marangoni;A. Oldani;Roberto Ratiglia;M. Raiteri;L. Berardinelli
目的应用彩色多普勒成像(CDI)评价具有拟交感神经活性的β受体阻滞剂(2%卡替洛尔)与不具有拟交感神经活性的β受体阻滞剂对原发性开角型青光眼(PDAG)患者眼血流动力学的影响。方法20例双眼POAG患者，眼压≤均为20 mm Hg，均用0.5%马来酸噻吗洛尔滴眼液治疗，2次/d。评估视野(Octopus 2000周长，G1程序)，检测平均敏感度(MS)和平均缺损值(MD)。CDI检测颈内动脉(ICA)、眼动脉(OA)、视网膜中央动脉(CRA)和睫状后短动脉(SPCA)的阻力指数。检查结束后改为2%卡替洛尔，每日2次。治疗6个月后，重复检查。数据采用t检验进行统计分析。结果0.5%卡替洛尔治疗期间平均眼压为16.7±1.67 mm Hg，2%卡替洛尔治疗后平均眼压为16.33±1.72 mm Hg，差异无统计学意义(p=0.494)。经2%卡替洛尔治疗6个月后，MS由22.4±2.5d B增至24.1±1.8d B(p=0.018)，平均缺损值(MD)由5.3±0.8d B降至4.7±0.6d B(p=0.011)。两种处理对CA、OA和CRA的阻力指数无显著差异，而对SPCA的阻力指数显著下降，从0.80±0.05降至0.77±0.02(p=0.017)。结论2%卡替洛尔治疗后CDI对内侧CA、OA和CRA的阻力指数无显著差异，但SPCA的阻力指数显著降低。2%卡替洛尔可引起视野检查指标的显著改变，其中MS增加，MD减少。提示卡替洛尔固有的拟交感神经活性可降低SCA的外周血管阻力，从而改善视神经头的灌流，从而对视功能起到保护作用。
Purpose To evaluate with color Doppler imaging (CDI), in patients with primary open-angle glaucoma (PDAG), the possible influence on ocular hemodynamics of a beta-blocking agent with intrinsic sympathomimetic acitivity (carteolol 2%) compared to a beta-blocker agent without this activity. Methods A study was carried out on 20 patients, with bilateral POaG, intraocular pressure (IOP) ≤ 20 mmHg, all treated twice a day with timolol maleate 0.5% ophthalmic solution. The visual field was evaluated (Octopus 2000 perimeter, G1 program) examining the mean sensitivity (MS) and the mean defect (MD). CDI was carried out to evaluate the resistance index of the internal carotid artery (ICA), the ophthalmic artery (OA), the central retinal artery (CRA), and the short posterior ciliary arteries (SPCA). After these examinations, the therapy was changed to carteolol 2% twice a day. After six months of treatment the examinations were repeated. The data were analysed statistically using Student's t test. Results The mean intraocular pressure during treatment with timolol 0.5% was 16.7 ± 1.67 mmHg and 16.33 ± 1.72 mmHg after treatment with carteolol 2%, the difference not being significant (p=0.494). After six months of treatment with carteolol 2% the MS increased significantly from 22.4 ± 2.5 dB to 24.1 ± 1.8 dB (p=0.018), and the mean defect (MD) fell from 5.3 ± 0.8 dB to 4.7 ± 0.6 dB (p=0.011). There was no significant difference in the resistance index of the CA, the OA and the CRA with the two treatments, whereas the resistance index of the SPCA dropped significantly, from 0.80 ± 0.05 to 0.77 ± 0.02 (p = 0.017). Conclusions CDI did not show significant differences in the resistance indexes of the internal CA, the OA, and the CRA after treatment with carteolol 2% but the resistance index of the SPCA was significantly reduced. Carteolol 2% induced significant changes in the perimetric indexes examined, with an increase in MS and a decrease in MD. These findings suggest that the intrinsic sympathomimetic activity of carteolol may reduce peripheral vascular resistance of the SCA, thus improving perfusion of the optic nerve head, with a protective effect on visual function.
影响因子：
13.7
作者：
J. Grunwald;C. E. Riva;Richard A. Stone;Edwin U. Keates;B. Petrig
通讯作者：
J. Grunwald;C. E. Riva;Richard A. Stone;Edwin U. Keates;B. Petrig