HTLV-III SEROPOSITIVITY IN EUROPEAN HAEMOPHILIACS EXPOSED TO FACTOR VIII CONCENTRATE IMPORTED FROM THE USA
HTLV-III SEROPOSITIVITY IN EUROPEAN HAEMOPHILIACS EXPOSED TO FACTOR VIII CONCENTRATE IMPORTED FROM THE USA
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接触从美国进口的因子 VIII 浓缩物的欧洲血友病患者的 HTLV-III 血清阳性
DOI：
10.1016/s0140-6736(84)91632-5
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
P. Ebbesen
中科院分区：
文献类型：
--
作者：
M. Melbye;R. Madhok;P. Sarin;G. Lowe;J. Goedert;K. Froebel;R. Biggar;S. Stenbjerg;C. Forbes;R. Gallo;P. Ebbesen
对77名苏格兰血友病患者和22名丹麦血友病患者进行了人类T细胞白血病病毒III（HTLV-III）抗体的血清学检测。自1979年以来，苏格兰患者主要接受苏格兰生产的凝血因子VIII浓缩物治疗，而除2例丹麦患者外，所有患者均接受了当地制备的浓缩物和由美国供体材料制成的商业浓缩物。15.6%的苏格兰和59.1%的丹麦血友病患者抗体阳性（p<0.001）。在1979年至1984年期间未接受治疗的11名血友病患者中，无一人血清反应阳性。仅接受当地生产的浓缩物治疗的30例受试者中有2例（6.7%）抗体阳性，而接受市售浓缩物治疗的58例受试者中有23例（39.7%）抗体阳性。在52名使用商业和当地生产的凝血因子VIII浓缩物的使用者中，血清阳性与商业浓缩物的消耗直接相关（p<0.001），但与当地生产的材料无关。这些数据表明，欧洲血友病患者暴露于HTLV-III通过一些因子VIII浓缩物从美国获得。
77 Scottish haemophiliacs and 22 Danish haemophiliacs were serologically tested for antibodies to human T-cell leukaemia virus III (HTLV-III). Since 1979 the Scottish patients had been treated largely with factor VIII concentrate produced in Scotland, whereas all but 2 of the Danish patients had received both locally prepared concentrate and commercial concentrate made from US donor material. 15·6% of Scottish and 59·1% of Danish haemophiliacs were antibody positive (p<0·001). None of 11 haemophiliacs not treated in the period 1979-84 was seropositive. 2 (6·7%) of 30 subjects who had been treated with locally produced concentrate only were antibody positive, compared with 23 (39·7%) of 58 subjects who had been treated with commercial concentrate. Among 52 users of both commercially and locally produced factor VIII concentrate, seropositivity was directly correlated with the consumption of commercial concentrate (p<0·001) but not locally produced material. These data indicate that European haemophiliacs were exposed to HTLV-III via some factor VIII concentrates obtained from the USA.
用冷沉淀和冻干浓缩物治疗的经典血友病患者的 T 淋巴细胞亚群。
DOI：
10.1056/nejm198301133080206
发表时间：
1983
期刊：
The New England journal of medicine
影响因子：
--
作者：
Menitove,JE;Aster,RH;Casper,JT;Lauer,SJ;Gottschall,JL;Williams,JE;Gill,JC;Wheeler,DV;Piaskowski,V;Kirchner,P;Montgomery,RR
通讯作者：
Montgomery,RR
典型血友病患者细胞介导的免疫力受损。
DOI：
10.1056/nejm198301133080205
发表时间：
1983
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lederman,MM;Ratnoff,OD;Scillian,JJ;Jones,PK;Schacter,B
通讯作者：
Schacter,B