Intracellular complement - the complosome - in immune cell regulation.
Intracellular complement - the complosome - in immune cell regulation.
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DOI：
10.1016/j.molimm.2017.05.012
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发表时间：
2017-09
影响因子：
3.6
通讯作者：
Kolev M
中科院分区：
文献类型：
--
作者：
Arbore G;Kemper C;Kolev M
最近的证据表明细胞内补体蛋白的存在及其激活（复合体）。复合体在新陈代谢等基本细胞过程中发挥作用。复合体和细胞内病原体之间的相互作用需要进一步阐明。补体系统在一个多世纪前就被定义为基于其“补充”抗体介导和细胞介导的针对病原体的免疫反应的能力。今天，我们对先天免疫这个古老部分的理解已经发生了很大的变化，我们现在知道补体在先天免疫和适应性免疫的调节中发挥着无可争议的关键作用。补体系统由 50 多种血液循环、细胞表面表达和细胞内蛋白质组成。它是识别和消除入侵病原体以及消除凋亡细胞等自身危险的关键，并且它支持先天免疫反应和一般炎症反应的启动。长期以来流行的补体经典观点是血清操作危险传感器和第一道防线系统，然而，最近的实验和临床证据表明，“局部”组织和令人惊讶的细胞内补体（复合体）激活对正常细胞生理学有影响。本综述将重点关注细胞内补体激活的新方面及其在新陈代谢等基本细胞过程中意想不到的作用。我们还讨论了复合体的存在对于宿主如何处理细胞内病原体（例如病毒）的潜在意义。
Recent, evidence have demonstrated presence of intracellular complement proteins and their activation (the complosome). The complosome plays a role in basic cell processes such as metabolism. The interaction between the complosome and intracellular pathogens needs to be further elucidated. The complement system was defined over a century ago based on its ability to “complement” the antibody-mediated and cell-mediated immune responses against pathogens. Today our understanding of this ancient part of innate immunity has changed substantially and we know now that complement plays an undisputed pivotal role in the regulation of both innate and adaptive immunity. The complement system consists of over 50 blood-circulating, cell-surface expressed and intracellular proteins. It is key in the recognition and elimination of invading pathogens, also in the removal of self-derived danger such as apoptotic cells, and it supports innate immune responses and the initiation of the general inflammatory reactions. The long prevailing classic view of complement was that of a serum-operative danger sensor and first line of defence system, however, recent experimental and clinical evidences have demonstrated that “local” tissue and surprisingly intracellular complement (the complosome) activation impacts on normal cell physiology. This review will focus on novel aspects of intracellular complement activation and its unexpected roles in basic cell processes such as metabolism. We also discuss what the existence of the complosome potentially means for how the host handles intracellular pathogens such as viruses.
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影响因子：
4.6
作者：
Haggadone MD;Grailer JJ;Fattahi F;Zetoune FS;Ward PA
通讯作者：
Ward PA
影响因子：
64.5
作者：
Chang CH;Curtis JD;Maggi LB Jr;Faubert B;Villarino AV;O'Sullivan D;Huang SC;van der Windt GJ;Blagih J;Qiu J;Weber JD;Pearce EJ;Jones RG;Pearce EL
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Pearce EL
影响因子：
0.7
作者：
Afrookhteh, Abolfazl;Emamgholipour, Solaleh;Shanaki, Mehrnoosh
通讯作者：
Shanaki, Mehrnoosh
T 辅助细胞 1 免疫需要 CD4⁺ T 细胞中补体驱动的 NLRP3 炎性体活性。
DOI：
10.1126/science.aad1210
发表时间：
2016-06-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arbore G;West EE;Spolski R;Robertson AAB;Klos A;Rheinheimer C;Dutow P;Woodruff TM;Yu ZX;O'Neill LA;Coll RC;Sher A;Leonard WJ;Köhl J;Monk P;Cooper MA;Arno M;Afzali B;Lachmann HJ;Cope AP;Mayer-Barber KD;Kemper C
通讯作者：
Kemper C
影响因子：
8.7
作者：
Freeley S;Kemper C;Le Friec G
通讯作者：
Le Friec G