Mesenchymal stem cells in arthritic diseases.
Mesenchymal stem cells in arthritic diseases.
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DOI：
10.1186/ar2514
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发表时间：
2008
影响因子：
4.9
通讯作者：
Tuan RS
中科院分区：
文献类型：
--
作者：
Chen FH;Tuan RS
间充质干细胞（MSCs）是在多种成人组织中发现的非造血祖细胞，其特点是易于分离且在体外能快速生长，同时保持分化潜能，从而能够进行大量培养扩增以获得适合治疗用途的大量细胞。这些特性使间充质干细胞成为组织工程中用于再生替代组织和修复各种关节炎病症中受损结构的理想候选细胞类型。骨关节炎（OA）是最常见的关节炎病症，与类风湿关节炎（RA）一样，呈现出一种有免疫参与的炎症环境，这一直是一个可能限制软骨组织工程应用的持久障碍。我们对间充质干细胞功能的理解的最新进展表明，间充质干细胞还具有强大的免疫抑制和抗炎作用。此外，通过分泌各种可溶性因子，间充质干细胞能够影响局部组织环境并发挥保护作用，最终有效地刺激原位再生。间充质干细胞的这一功能可用于其在类风湿关节炎和骨关节炎等退行性关节疾病中的治疗应用。本综述概述了过去十年所取得的进展，这些进展使我们对与关节疾病相关的干细胞生物学有了当前的认识。还将讨论间充质干细胞在退行性关节疾病病理生理学中的潜在作用。具体而言，我们将通过组织工程对受损软骨进行功能性替代以及利用其抗炎和免疫抑制活性，探讨基于间充质干细胞的细胞疗法在骨关节炎和类风湿关节炎治疗中的潜力。
Mesenchymal stem cells (MSCs), the nonhematopoietic progenitor cells found in various adult tissues, are characterized by their ease of isolation and their rapid growth in vitro while maintaining their differentiation potential, allowing for extensive culture expansion to obtain large quantities suitable for therapeutic use. These properties make MSCs an ideal candidate cell type as building blocks for tissue engineering efforts to regenerate replacement tissues and repair damaged structures as encountered in various arthritic conditions. Osteoarthritis (OA) is the most common arthritic condition and, like rheumatoid arthritis (RA), presents an inflammatory environment with immunological involvement and this has been an enduring obstacle that can potentially limit the use of cartilage tissue engineering. Recent advances in our understanding of the functions of MSCs have shown that MSCs also possess potent immunosuppression and anti-inflammation effects. In addition, through secretion of various soluble factors, MSCs can influence the local tissue environment and exert protective effects with an end result of effectively stimulating regeneration in situ. This function of MSCs can be exploited for their therapeutic application in degenerative joint diseases such as RA and OA. This review surveys the advances made in the past decade which have led to our current understanding of stem cell biology as relevant to diseases of the joint. The potential involvement of MSCs in the pathophysiology of degenerative joint diseases will also be discussed. Specifically, we will explore the potential of MSC-based cell therapy of OA and RA by means of functional replacement of damaged cartilage via tissue engineering as well as their anti-inflammatory and immunosuppressive activities.
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影响因子：
5.1
作者：
Guo, Jun;Lin, Guo-sheng;Hu, Ming-yan
通讯作者：
Hu, Ming-yan
影响因子：
2.6
作者：
Bartholomew, A;Sturgeon, C;Hoffman, R
通讯作者：
Hoffman, R
影响因子：
20.3
作者：
Almeida-Porada, G;Porada, CD;Zanjani, ED
通讯作者：
Zanjani, ED
影响因子：
20.3
作者：
Aggarwal, S;Pittenger, MF
通讯作者：
Pittenger, MF
影响因子：
20.3
作者：
Beyth, S;Borovsky, Z;Rachmilewitz, J
通讯作者：
Rachmilewitz, J