Oncogenic reg IV is a novel prognostic marker for glioma patient survival.
Oncogenic reg IV is a novel prognostic marker for glioma patient survival.
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DOI：
10.1186/1746-1596-7-69
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发表时间：
2012-06-19
影响因子：
2.6
通讯作者：
Tu Y
中科院分区：
文献类型：
--
作者：
Wang Q;Deng J;Yuan J;Wang L;Zhao Z;He S;Zhang Y;Tu Y
再生胰岛衍生家族成员4（Reg IV）的异常表达已在多种人类癌症中发现。然而，Reg IV基因及其编码产物在人脑胶质瘤中的作用还不清楚。因此，本研究旨在探讨Reg IV在胶质瘤中表达的临床病理意义。采用实时荧光定量RT-PCR、Western blot和免疫组化方法分别检测人脑胶质瘤和非肿瘤脑组织中Reg IV mRNA和蛋白的表达。还统计分析了Reg IV免疫染色与胶质瘤患者临床病理因素和预后的相关性。胶质瘤组织中Reg IV mRNA和蛋白的表达水平均显著高于相应的非肿瘤脑组织（P均< 0.001）。此外，胶质瘤组织中Reg IV免疫染色的增加与晚期病理分级显著相关（P = 0.008）。Reg IV蛋白上调也与低Karnofsky表现评分（KPS）显著相关（P = 0.02）。此外，Reg IV蛋白高表达患者的总生存期明显短于Reg IV蛋白低表达患者（P < 0.001）。多因素考克斯回归分析进一步证实Reg IV表达是胶质瘤患者的独立预后因素（P = 0.008）。这些令人信服的证据首次表明，Reg IV可能加速疾病进展，并作为胶质瘤的候选预后标志物。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/2145344361720706
The aberrant expression of regenerating islet-derived family member, 4 (Reg IV) has been found in various human cancers. However, the roles of Reg IV gene and its encoding product in human glioma have not been clearly understood. Therefore, the aim of this study was to investigate the clinicopathological significance of Reg IV expression in glioma. Reg IV mRNA and protein expression in human gliomas and non-neoplastic brain tissues were respectively detected by real-time quantitative RT-PCR assay, Western blot, and immunohistochemistry. The association of Reg IV immunostaining with clinicopathological factors and prognosis of glioma patients was also statistically analyzed. Reg IV mRNA and protein expression levels in glioma tissues were both significantly higher than those in the corresponding non-neoplastic brain tissues (both P < 0.001). Additionally, the increased Reg IV immunostaining in glioma tissues was significantly associated with advanced pathological grade (P = 0.008). Reg IV protein up-regulation was also significantly correlated with low Karnofsky performance score (KPS) (P = 0.02). Moreover, the overall survival of patients with high Reg IV protein expression was dramatically shorter than those with low Reg IV protein expression (P < 0.001). Multivariate Cox regression analysis further confirmed that Reg IV expression was an independent prognostic factor for patients with gliomas (P = 0.008). These convinced evidences suggest for the first time that Reg IV might accelerate disease progression and act as a candidate prognostic marker for gliomas. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2145344361720706
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影响因子：
29.4
作者：
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通讯作者：
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