Immune infiltrates as predictive markers of survival in pancreatic cancer patients.
Immune infiltrates as predictive markers of survival in pancreatic cancer patients.
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DOI：
10.3389/fphys.2013.00210
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发表时间：
2013
影响因子：
4
通讯作者：
De Monte L
中科院分区：
文献类型：
--
作者：
Protti MP;De Monte L
胰腺癌是一种预后不良的毁灭性疾病。肿瘤微环境由多种细胞类型、分子因子和细胞外基质组成，形成强烈的促纤维增生反应，这是疾病的标志。肿瘤细胞和间质之间存在复杂的相互影响，决定了肿瘤的进展和最终的临床结果。在此背景下，肿瘤浸润的免疫细胞通过分泌趋化因子和细胞因子发挥重要的调节作用。在这里，我们回顾了免疫浸润之间的相关性，对胰腺癌患者接受手术切除，无病和/或手术后的总生存率的肿瘤样本进行评估。具体来说，我们专注于肿瘤浸润淋巴细胞（TIL），肥大细胞（MC）和巨噬细胞，都有助于Th 2型炎症和免疫抑制微环境。在这些患者中，肿瘤免疫浸润不仅无助于疾病根除，而且Th 2型炎症和免疫抑制的特征与更快的疾病进展和降低的生存率显著相关。
Pancreatic cancer is a devastating disease with dismal prognosis. The tumor microenvironment is composed by multiple cell types, molecular factors, and extracellular matrix forming a strong desmoplastic reaction, which is a hallmark of the disease. A complex cross-talk between tumor cells and the stroma exists with reciprocal influence that dictates tumor progression and ultimately the clinical outcome. In this context, tumor infiltrating immune cells through secretion of chemokine and cytokines exert an important regulatory role. Here we review the correlation between the immune infiltrates, evaluated on tumor samples of pancreatic cancer patients underwent surgical resection, and disease free and/or overall survival after surgery. Specifically, we focus on tumor infiltrating lymphocytes (TILs), mast cells (MCs) and macrophages that all contribute to a Th2-type inflammatory and immunosuppressive microenvironment. In these patients tumor immune infiltrates not only do not contribute to disease eradication but rather the features of Th2-type inflammation and immunosuppression is significantly associated with more rapid disease progression and reduced survival.
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影响因子：
7.4
作者：
Galon J;Pagès F;Marincola FM;Angell HK;Thurin M;Lugli A;Zlobec I;Berger A;Bifulco C;Botti G;Tatangelo F;Britten CM;Kreiter S;Chouchane L;Delrio P;Arndt H;Asslaber M;Maio M;Masucci GV;Mihm M;Vidal-Vanaclocha F;Allison JP;Gnjatic S;Hakansson L;Huber C;Singh-Jasuja H;Ottensmeier C;Zwierzina H;Laghi L;Grizzi F;Ohashi PS;Shaw PA;Clarke BA;Wouters BG;Kawakami Y;Hazama S;Okuno K;Wang E;O'Donnell-Tormey J;Lagorce C;Pawelec G;Nishimura MI;Hawkins R;Lapointe R;Lundqvist A;Khleif SN;Ogino S;Gibbs P;Waring P;Sato N;Torigoe T;Itoh K;Patel PS;Shukla SN;Palmqvist R;Nagtegaal ID;Wang Y;D'Arrigo C;Kopetz S;Sinicrope FA;Trinchieri G;Gajewski TF;Ascierto PA;Fox BA
通讯作者：
Fox BA
影响因子：
8.8
作者：
Ino Y;Yamazaki-Itoh R;Shimada K;Iwasaki M;Kosuge T;Kanai Y;Hiraoka N
通讯作者：
Hiraoka N
肿瘤微环境中的肥大细胞促进了胰腺导管腺癌的体内生长。
DOI：
10.1158/1078-0432.ccr-11-0607
发表时间：
2011-11-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Chang DZ;Ma Y;Ji B;Wang H;Deng D;Liu Y;Abbruzzese JL;Liu YJ;Logsdon CD;Hwu P
通讯作者：
Hwu P
影响因子：
50.3
作者：
Hanahan, Douglas;Coussens, Lisa M.
通讯作者：
Coussens, Lisa M.
DOI：
10.1084/jem.20101876
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
De Monte L;Reni M;Tassi E;Clavenna D;Papa I;Recalde H;Braga M;Di Carlo V;Doglioni C;Protti MP
通讯作者：
Protti MP