An immunological overview of allergen specific immunotherapy — subcutaneous and sublingual routes
An immunological overview of allergen specific immunotherapy — subcutaneous and sublingual routes
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过敏原特异性免疫治疗的免疫学概述——皮下和舌下途径
DOI：
10.1177/1753465809349522
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发表时间：
2009
影响因子：
4.3
通讯作者：
C. Ozdemir
中科院分区：
文献类型：
--
作者：
C. Ozdemir
过敏原特异性免疫疗法仍然是变态反应性疾病最有可能的有效治疗方式，它针对潜在的免疫机制，可能导致病程的改变，以及治疗症状。近一个世纪以来，注射型变态反应原特异性免疫疗法的治疗和依从性经验推动了新的、替代路线的发展。不良事件和安全顾虑、疗效和易用性似乎是这种治疗方式舌下形式发展的刺激因素，其中主要因素是在出现口服耐受的部位被树突状细胞捕获抗原(过敏原)。由于该区域存在大量的致耐受树突状细胞亚群，导致免疫系统编程进入对特定过敏原无反应的调节状态。通过产生调节性T细胞诱导外周免疫耐受是关键事件，在过敏免疫反应中有几种功能调节。随着对调节通路机制的了解的增加，过敏原特异性免疫治疗领域将取得有希望的进展，并可能为变态反应性疾病的治疗提供新的选择。
Allergen-specific immunotherapy remains the most likely effective treatment modality for allergic disorders by targeting the underlying immune mechanisms and possibly causing modifications in the disease course, as well as treating the symptoms. Treatment and compliance experiences been gained over nearly a century in injection-type allergen-specific immunotherapy have motivated the development of newer, alternative routes. Adverse events and safety concerns, efficacy and ease of application seem to be the stimulating factors for the development of a sublingual form of this treatment modality, wherein the principal factor is the capture of the antigen (allergen) by dendritic cells, in the location where oral tolerance arises. Due to the presence of high numbers of tolerogenic dendritic cell subsets in this region, programming of the immune system towards a regulatory state with unresponsiveness to specific allergens occurs. Induction of peripheral tolerance through the generation of regulatory T cells is the key event, with several functional modulations in the allergic immune response. With an increase in understanding of the mechanism of regulatory pathways, promising progresses in the field of allergen-specific immunotherapy will ensue and may provide new options for the treatment of allergic disorders.
影响因子：
56.9
作者：
FREEMAN, GJ;GRIBBEN, JG;NADLER, LM
通讯作者：
NADLER, LM
影响因子：
2.8
作者：
J. Mullol;C. Bachert;J. Bousquet
通讯作者：
J. Mullol;C. Bachert;J. Bousquet
影响因子：
14.2
作者：
FURIN, MJ;NORMAN, PS;NACLERIO, RM
通讯作者：
NACLERIO, RM