The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index.
The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index.
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DOI：
10.3389/fcvm.2022.821151
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发表时间：
2022
影响因子：
3.6
通讯作者：
Barnes JN
中科院分区：
文献类型：
--
作者：
Fico BG;Miller KB;Rivera-Rivera LA;Corkery AT;Pearson AG;Eisenmann NA;Howery AJ;Rowley HA;Johnson KM;Johnson SC;Wieben O;Barnes JN
中央动脉抑制心肌收缩产生的脉动力，限制到达脑脉管系统的脉动，尽管关于这种与人类衰老关系的数据有限。本研究的目的是确定年轻人和老年人的主动脉僵硬度与脑动脉搏动指数之间的关联。我们假设大脑搏动指数与老年人的主动脉僵硬度有关，但与年轻人无关。我们还假设年龄和主动脉僵硬度都是脑搏动指数的重要预测因素。这项研究包括 23 名健康老年人（年龄 62 ± 6 岁）和 33 名健康年轻人（年龄 25 ± 4 岁）。使用颈动脉-股动脉脉搏波速度 (cfPWV) 测量主动脉僵硬度，同时使用 4D Flow MRI 评估颈内动脉 (ICA)、大脑中动脉 (MCA) 和基底动脉的脑动脉搏动指数。脑搏动指数计算为（最大流量 - 最小流量）/平均流量。在合并年龄组中，cfPWV 与 ICA（r = 0.487；p < 0.001）、MCA（r = 0.393；p = 0.003）和基底动脉（r = 0.576；p < 0.001）的脑搏动指数呈正相关。在年轻人中，cfPWV 与任何感兴趣动脉的脑搏动指数之间均无关联（ICA：r = 0.253；p = 0.156，MCA：r = -0.059；p = 0.743，基底动脉 r = 0.171；p = 0.344）。相反，在老年人中，cfPWV 与 MCA（r = 0.437；p = 0.037）和基底动脉（r = 0.500；p = 0.015）的脑搏动指数呈正相关。然而，老年人 ICA 中 cfPWV 和脑搏动指数之间的关系并未达到显着性阈值（r = 0.375；p = 0.078）。总之，年龄和主动脉僵硬度是健康成年人脑动脉搏动指数的重要预测因素。这项研究强调了在日益老龄化的人口中针对主动脉僵硬度的重要性，以减轻与年龄相关的脑血流动力学变化的负担。
The central arteries dampen the pulsatile forces from myocardial contraction, limiting the pulsatility that reaches the cerebral vasculature, although there are limited data on this relationship with aging in humans. The purpose of this study was to determine the association between aortic stiffness and cerebral artery pulsatility index in young and older adults. We hypothesized that cerebral pulsatility index would be associated with aortic stiffness in older adults, but not in young adults. We also hypothesized that both age and aortic stiffness would be significant predictors for cerebral pulsatility index. This study included 23 healthy older adults (aged 62 ± 6 years) and 33 healthy young adults (aged 25 ± 4 years). Aortic stiffness was measured using carotid-femoral pulse wave velocity (cfPWV), while cerebral artery pulsatility index in the internal carotid arteries (ICAs), middle cerebral arteries (MCAs), and basilar artery were assessed using 4D Flow MRI. Cerebral pulsatility index was calculated as (maximum flow – minimum flow) / mean flow. In the combined age group, there was a positive association between cfPWV and cerebral pulsatility index in the ICAs (r = 0.487; p < 0.001), MCAs (r = 0.393; p = 0.003), and basilar artery (r = 0.576; p < 0.001). In young adults, there were no associations between cfPWV and cerebral pulsatility index in any of the arteries of interest (ICAs: r = 0.253; p = 0.156, MCAs: r = −0.059; p = 0.743, basilar artery r = 0.171; p = 0.344). In contrast, in older adults there was a positive association between cfPWV and cerebral pulsatility index in the MCAs (r = 0.437; p = 0.037) and basilar artery (r = 0.500; p = 0.015). However, the relationship between cfPWV and cerebral pulsatility index in the ICAs of the older adults did not reach the threshold for significance (r = 0.375; p = 0.078). In conclusion, age and aortic stiffness are significant predictors of cerebral artery pulsatility index in healthy adults. This study highlights the importance of targeting aortic stiffness in our increasingly aging population to reduce the burden of age-related changes in cerebral hemodynamics.
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影响因子：
8.3
作者：
Mitchell, GF;Parise, H;Levy, D
通讯作者：
Levy, D
影响因子：
4.4
作者：
Loecher, Michael;Schrauben, Eric;Wieben, Oliver
通讯作者：
Wieben, Oliver
影响因子：
2.4
作者：
Kidwell, CS;El-Saden, S;Saver, JL
通讯作者：
Saver, JL
影响因子：
4
作者：
Miller KB;Howery AJ;Harvey RE;Eldridge MW;Barnes JN
通讯作者：
Barnes JN
影响因子：
37.8
作者：
Mitchell GF;Wang N;Palmisano JN;Larson MG;Hamburg NM;Vita JA;Levy D;Benjamin EJ;Vasan RS
通讯作者：
Vasan RS