Cerebrovascular Reactivity and Central Arterial Stiffness in Habitually Exercising Healthy Adults.
Cerebrovascular Reactivity and Central Arterial Stiffness in Habitually Exercising Healthy Adults.
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DOI：
10.3389/fphys.2018.01096
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发表时间：
2018
影响因子：
4
通讯作者：
Barnes JN
中科院分区：
文献类型：
--
作者：
Miller KB;Howery AJ;Harvey RE;Eldridge MW;Barnes JN
脑血管对血管活性刺激的反应性降低与中风和认知能力下降等与年龄有关的疾病有关。习惯性的锻炼可以防止认知能力下降，还可以降低灌注大脑的大中枢动脉的硬度。在此背景下，我们评估了习惯运动的健康成年人脑血管反应性的年龄相关差异。此外，我们试图确定中央动脉硬度和脑血管反应性之间的关系。我们招募了22名年轻（年龄= 27±5岁，范围18-35岁）和21名老年（年龄= 60±4岁，范围56-68岁）的习惯性锻炼者，他们每周至少参加150分钟的有组织的有氧运动。经颅多普勒超声记录大脑中动脉流速（MCAv）。为了评估脑血管反应性，在静息和逐步升高二氧化碳浓度2,4和6%时，连续记录MCAv、末潮二氧化碳（ETCO2）和平均动脉压（MAP）。脑血管传导指数（CVCi）以MCAv/MAP计算。采用颈-股脉波速度（PWV）评估中心动脉硬度。老年人的PWV （YA: 6.2±1.2 m/s; OA: 7.5±1.3 m/s; p < 0.05）高于年轻人。MCAv和CVCi对高碳酸血症的反应性在年轻人和老年人之间没有差异（MCAv反应性，YA: 2.0±0.2 cm/s/mmHg, OA: 2.0±0.2 cm/s/mmHg, p = 0.77， CVCi反应性，YA: 0.018±0.002 cm/s/mmHg2, OA: 0.015±0.001 cm/s/mmHg2, p = 0.27）；然而，老年人对高碳酸血症表现出更高的MAP反应性（YA: 0.4±0.1 mmHg/mmHg; OA: 0.7±0.1 mmHg/mmHg; p < 0.05）。PWV与脑血管反应性无相关性（r = 0.00-0.39; p = 0.07-0.99）。我们的研究结果表明，脑血管反应性在习惯运动的年轻人和老年人之间没有差异；然而，MAP反应性在老年人中增强。这表明在高碳酸血症期间依赖MAP增加脑血流量的年龄相关差异。
Reduced cerebrovascular reactivity to a vasoactive stimulus is associated with age-related diseases such as stroke and cognitive decline. Habitual exercise is protective against cognitive decline and is associated with reduced stiffness of the large central arteries that perfuse the brain. In this context, we evaluated the age-related differences in cerebrovascular reactivity in healthy adults who habitually exercise. In addition, we sought to determine the association between central arterial stiffness and cerebrovascular reactivity. We recruited 22 young (YA: age = 27 ± 5 years, range 18–35 years) and 21 older (OA: age = 60 ± 4 years, range 56–68 years) habitual exercisers who partake in at least 150 min of structured aerobic exercise each week. Middle cerebral artery velocity (MCAv) was recorded using transcranial Doppler ultrasound. In order to assess cerebrovascular reactivity, MCAv, end-tidal carbon dioxide (ETCO2), and mean arterial pressure (MAP) were continuously recorded at rest and during stepwise elevations of 2, 4, and 6% inhaled CO2. Cerebrovascular conductance index (CVCi) was calculated as MCAv/MAP. Central arterial stiffness was assessed using carotid–femoral pulse wave velocity (PWV). Older adults had higher PWV (YA: 6.2 ± 1.2 m/s; OA: 7.5 ± 1.3 m/s; p < 0.05) compared with young adults. MCAv and CVCi reactivity to hypercapnia were not different between young and older adults (MCAv reactivity, YA: 2.0 ± 0.2 cm/s/mmHg; OA: 2.0 ± 0.2 cm/s/mmHg; p = 0.77, CVCi reactivity, YA: 0.018 ± 0.002 cm/s/mmHg2; OA: 0.015 ± 0.001 cm/s/mmHg2; p = 0.27); however, older adults demonstrated higher MAP reactivity to hypercapnia (YA: 0.4 ± 0.1 mmHg/mmHg; OA: 0.7 ± 0.1 mmHg/mmHg; p < 0.05). There were no associations between PWV and cerebrovascular reactivity (range: r = 0.00–0.39; p = 0.07–0.99). Our results demonstrate that cerebrovascular reactivity was not different between young and older adults who habitually exercise; however, MAP reactivity was augmented in older adults. This suggests an age-associated difference in the reliance on MAP to increase cerebral blood flow during hypercapnia.
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影响因子：
8.3
作者：
BISHOP, CCR;POWELL, S;BROWSE, NL
通讯作者：
BROWSE, NL
影响因子：
3.3
作者：
Claassen, Jurgen A. H. R.;Zhang, Rong;Levine, Benjamin D.
通讯作者：
Levine, Benjamin D.
影响因子：
6
作者：
Barnes, Jill N.;Harvey, Ronee E.;Kantarci, Kejal
通讯作者：
Kantarci, Kejal
影响因子：
8.3
作者：
ILIFF, LD;ZILKHA, E;SYMON, L
通讯作者：
SYMON, L
影响因子：
8.3
作者：
Maillard P;Mitchell GF;Himali JJ;Beiser A;Fletcher E;Tsao CW;Pase MP;Satizabal CL;Vasan RS;Seshadri S;DeCarli C
通讯作者：
DeCarli C