Non Melanoma Skin Cancer Pathogenesis Overview.
Non Melanoma Skin Cancer Pathogenesis Overview.
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DOI：
10.3390/biomedicines6010006
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发表时间：
2018-01-02
期刊：
影响因子：
4.7
通讯作者：
Cantisani C
中科院分区：
文献类型：
--
作者：
Didona D;Paolino G;Bottoni U;Cantisani C
(1)背景：非黑色素瘤皮肤癌是人类最常见的癌症。皮肤癌的发生过程尚不完全清楚。然而，已经进行了几项研究以更好地解释导致恶性的机制；(2)方法：我们回顾了更新的关于非黑色素瘤皮肤癌发病机制的文献，重点是基底细胞癌、鳞状细胞癌和光化性角化病；(3)结果：几篇文献报道了导致非黑色素瘤皮肤癌的基因和分子改变。非黑色素瘤皮肤癌的发病机制涉及多个危险因素，包括遗传和分子改变、免疫抑制和紫外线辐射；(4)结论：尽管皮肤癌的发生尚不完全清楚，但已有多篇文献证明遗传和分子改变参与了这一过程。此外，现在已知了大量非黑色素瘤皮肤癌的危险因素，从而有效地预防了非黑色素瘤皮肤癌的发展。与其他关于同一主题的论文相比，我们的综述集中在分子和遗传因素上，并详细分析了与非黑色素瘤皮肤癌有关的几个因素。
(1) Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood. However, several studies have been conducted to better explain the mechanisms that lead to malignancy; (2) Methods: We reviewed the more recent literature about the pathogenesis of non-melanoma skin cancer focusing on basal cell carcinomas, squamous cell carcinoma and actinic keratosis; (3) Results: Several papers reported genetic and molecular alterations leading to non-melanoma skin cancer. Plenty of risk factors are involved in non-melanoma skin cancer pathogenesis, including genetic and molecular alterations, immunosuppression, and ultraviolet radiation; (4) Conclusion: Although skin carcinogenesis is still not fully understood, several papers demonstrated that genetic and molecular alterations are involved in this process. In addition, plenty of non-melanoma skin cancer risk factors are now known, allowing for an effective prevention of non-melanoma skin cancer development. Compared to other papers on the same topic, our review focused on molecular and genetic factors and analyzed in detail several factors involved in non-melanoma skin cancer.
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