Omega-3 and renal function in older adults.
Omega-3 and renal function in older adults.
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DOI：
10.2174/138161209789909719
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发表时间：
2009
影响因子：
3.1
通讯作者：
Ferrucci L
中科院分区：
文献类型：
--
作者：
Lauretani F;Maggio M;Pizzarelli F;Michelassi S;Ruggiero C;Ceda GP;Bandinelli S;Ferrucci L
慢性肾病（CKD）是一个主要的公共卫生问题，可能导致需要透析或移植的终末期肾病。在欧洲，高达 12% 的成年人口患有一定程度的肾功能损害，而在美国，慢性肾病 (CKD) 末期患者人数急剧增加，从 1991 年的 209,000 人增加到 2004 年的 472,000 人。糖尿病和高血压是肾脏病理的主要原因。随着年龄的增长，感染，特别是上行感染更加常见，因为免疫功能下降，并且导致感染的相关病理（例如梗阻性尿路病）变得更加常见。肾脏的大多数病理变化似乎是由氧化应激引发的，随后是炎症反应。氧化应激是由自由基与内源性和外源性清除剂（包括多不饱和脂肪酸（PUFA））解毒之间的不平衡引起的。最近的研究表明，补充 PUFA 可以减缓 IgA 肾病患者肾功能丧失的速度。然后，对透析患者补充 omega-3 的研究描述了对甘油三酯水平和透析通路通畅的有益影响。我们对参加 InCHIANTI 研究的老年人进行了为期三年的随访，研究了总血浆 PUFA 水平与肌酐清除率变化之间的关系，InCHIANTI 研究是一项在意大利托斯卡纳进行的基于人群的流行病学研究。这项研究表明，血浆总 PUFA 水平较低的老年人在三年的随访中肌酐清除率下降幅度更大。这些研究结果表明，饮食中摄入较高的多不饱和脂肪酸可能有助于防止进展为慢性肾病。
Chronic kidney disease (CKD) is a major public health problem and can result in end-stage renal disease with need for dialysis or transplantation. In Europe up to 12% of the adult population had some renal impairment, while in the United States the end stage of CKD has increased dramatically from 209.000 in 1991 to 472.000 in 2004. Diabetes and hypertension are major causes of kidney pathology. Infection, particularly ascending infection, is more common with increasing age, as both immune function declines and associated pathology predisposing to infection, such as obstructive uropathy, becomes more common. Most pathological changes in the kidney appear to be initiated by oxidative stress, followed by an inflammatory reaction. Oxidative stress results from an imbalance between free radicals and their detoxification by endogenous and exogenous scavengers, including polyunsatured fatty acids (PUFA). Recent studies showed that PUFA supplementation slowed the rate of loss of renal function in patients with IgA nephropathy. Then, studies of omega-3 supplementation in dialysis patients describe salutary effects on triglyceride levels and dialysis access patency. We examined the relationship between total plasma PUFA levels and change in creatinine clearance over a three-year follow-up in the older persons enrolled in the InCHIANTI study, a population-based epidemiology study conducted in Tuscany, Italy. This study showed that older adults with low total plasma PUFA levels have a greater decline in creatinine clearance over three years of follow-up. These findings suggest that a higher dietary intake of PUFA may be protective against progression to chronic kidney disease.
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影响因子：
5.8
作者：
Ferrucci, L;Cherubini, A;Guralnik, JM
通讯作者：
Guralnik, JM
影响因子：
158.5
作者：
DONADIO, JV;BERGSTRALH, EJ;HOLLEY, KE
通讯作者：
HOLLEY, KE
影响因子：
4.3
作者：
deJonge, HW;Dekkers, DHW;Lamers, JMJ
通讯作者：
Lamers, JMJ
影响因子：
13.2
作者：
Coresh, J;Astor, BC;Levey, AS
通讯作者：
Levey, AS
影响因子：
120.7
作者：
Coresh, Josef;Selvin, Elizabeth;Levey, Andrew S.
通讯作者：
Levey, Andrew S.