Polymeric lipid assemblies as novel theranostic tools.
Polymeric lipid assemblies as novel theranostic tools.
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DOI：
10.1021/ar2001843
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发表时间：
2011-10-18
影响因子：
18.3
通讯作者：
Blumenthal, Robert
中科院分区：
文献类型：
--
作者：
Puri, Anu;Blumenthal, Robert
可聚合脂类已用于研究和医学应用，如膜模型、成像平台、药物输送系统、疫苗载体、生物传感器和涂层材料。这些脂质分子的聚合形成了脂质部分之间的共价键，这改善了非共价相互作用，维持了脂质层状相结构，增加了聚合体系的稳定性。由于这些脂质分子形成具有可修饰结构的纳米组件，在共价键形成后获得聚合物的稳定性，因此这些脂质在新兴的治疗学领域具有相当大的兴趣。在这篇文章中，我们总结了可聚合脂类（主要是磷脂）在各种纳米平台中的生物医学应用。我们讨论了稳定的纳米平台，它已被用于各种治疗应用。此外，我们描述了通过将适当的非聚合脂质与可聚合脂质结合来组装可触发治疗药物的方法。高分子脂质在医学成像、靶向和按需给药领域具有纳米工具的前景。由于它们与生物脂质相似，可聚合脂质纳米平台的长期毒性问题预计是最小的。尽管聚合物纳米胶囊领域仍处于发展阶段，但人们正在加紧努力，生产可用于疾病诊断和治疗的系统。我们设想，纳米成像平台结合局部给药技术将对癌症治疗和其他相关疾病产生重大影响。在显像剂和/或药物的光化学以及利用光对这些药物进行修饰方面，现有的丰富临床知识将证明对进一步开发聚合治疗性脂基纳米颗粒有价值。
Polymerizable lipids have been used in research and medical applications such as membrane models, imaging platforms, drug delivery systems, vaccine carriers, biosensors, and coating materials. The polymerization of these lipid molecules forms a covalent bond between lipid moieties, which improves the noncovalent interactions that maintain the lipid lamellar phase architecture and increases the stability of the polymerized system. Because such lipid molecules form nanoassemblies with modifiable structures that acquire the stability of polymers following covalent bond formation, these lipids are of considerable interest in the emerging field of theranostics.In this Account, we summarize the biomedical applications of polymerizable lipids (primarily phospholipids) in the context of various nanoplatforms. We discuss stable nanoplatforms, which have been used in a variety of theranostics applications. In addition, we describe methods for assembling triggerable theranostics by combining appropriate nonpolymerizable lipids with polymerizable lipids.Polymeric lipids hold promise as nanotools in the field of medical imaging, targeting, and on-demand drug delivery. Because of their similarity to biological lipids, long-term toxicity issues from polymerizable lipid nanoplatforms are predicted to be minimal. Although the field of polymeric nanocapsules is still in development, intensive efforts are underway to produce systems which could be applied to disease diagnosis and treatment. We envision that nanoimaging platforms coupled with localized drug delivery technology will have a significant impact on cancer therapy and other related diseases. The existing wealth of clinical knowledge both in the photochemistry of imaging agents and/or drugs and modifications of these agents using light will prove valuable in the further development of polymeric theranostic lipid-based nanoparticles.
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DOI：
10.1039/c0cc00784f
发表时间：
2010-08-21
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
作者：
Kumar A;Erasquin UJ;Qin G;Li K;Cai C
通讯作者：
Cai C
DOI：
10.1016/0166-6622(91)80021-f
发表时间：
1991-01-30
期刊：
COLLOIDS AND SURFACES
影响因子：
--
作者：
BONOSI, F;GABRIELLI, G
通讯作者：
GABRIELLI, G
影响因子：
5.5
作者：
Clapp, PJ;Armitage, BA;OBrien, DF
通讯作者：
OBrien, DF
DOI：
10.1016/0304-4165(87)90032-8
发表时间：
1987-05-19
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
FREEMAN, FJ;HAYWARD, JA;CHAPMAN, D
通讯作者：
CHAPMAN, D
影响因子：
3.8
作者：
KRAUSE, HJ;JULIANO, RL;REGEN, S
通讯作者：
REGEN, S