Selection for antibiotic resistance is reduced when embedded in a natural microbial community
Selection for antibiotic resistance is reduced when embedded in a natural microbial community
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当嵌入天然微生物群落时，抗生素耐药性的选择就会减少
DOI：
10.1101/529651
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Klümper U
中科院分区：
文献类型：
--
作者：
Klümper U
Antibiotic resistance has emerged as one of the most pressing, global threats to public health. In single-species experiments selection for antibiotic resistance occurs at very low antibiotic concentrations. However, it is unclear how far these findings can be extrapolated to natural environments, where species are embedded within complex communities. We competed isogenic strains ofEscherichia coli, differing exclusively in a single chromosomal resistance determinant, in the presence and absence of a pig fecal microbial community across a gradient of antibiotic concentration for two relevant antibiotics: gentamicin and kanamycin. We show that the minimal selective concentration was increased by more than one order of magnitude for both antibiotics when embedded in the community. We identified two general mechanisms were responsible for the increase in minimal selective concentration: an increase in the cost of resistance and a protective effect of the community for the susceptible phenotype. These findings have implications for our understanding of the evolution and selection of antibiotic resistance, and can inform future risk assessment efforts on antibiotic concentrations.
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影响因子：
11.8
作者：
Drlica, Karl;Zhao, Xilin
通讯作者：
Zhao, Xilin
影响因子：
8.9
作者：
Arias-Andres, Maria;Kluemper, Uli;Grossart, Hans-Peter
通讯作者：
Grossart, Hans-Peter
影响因子：
14.9
作者：
Nilsson RH;Larsson KH;Taylor AFS;Bengtsson-Palme J;Jeppesen TS;Schigel D;Kennedy P;Picard K;Glöckner FO;Tedersoo L;Saar I;Kõljalg U;Abarenkov K
通讯作者：
Abarenkov K
DOI：
10.1098/rspb.2000.1354
发表时间：
2001-02-07
影响因子：
4.7
作者：
Kraaijeveld, AR;Limentani, EC;Godfray, HCJ
通讯作者：
Godfray, HCJ